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Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases
Migrasomes are migration-dependent membrane-bound vesicular structures that contain cellular contents and small vesicles. Migrasomes grow on the tips or intersections of the retraction fibers after cells migrate away. The process of releasing migrasomes into the extracellular space is named as “migr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023195/ https://www.ncbi.nlm.nih.gov/pubmed/35464764 http://dx.doi.org/10.1155/2022/4525778 |
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author | Zhang, Yaxing Guo, Wenhai Bi, Mingmin Liu, Wei Zhou, Lequan Liu, Haimei Yan, Fuman Guan, Li Zhang, Jiongshan Xu, Jinwen |
author_facet | Zhang, Yaxing Guo, Wenhai Bi, Mingmin Liu, Wei Zhou, Lequan Liu, Haimei Yan, Fuman Guan, Li Zhang, Jiongshan Xu, Jinwen |
author_sort | Zhang, Yaxing |
collection | PubMed |
description | Migrasomes are migration-dependent membrane-bound vesicular structures that contain cellular contents and small vesicles. Migrasomes grow on the tips or intersections of the retraction fibers after cells migrate away. The process of releasing migrasomes into the extracellular space is named as “migracytosis”. After releasing, they can be taken up by the surrounding cells, or rupture and further release their contents into the extracellular environment. Physiologically, migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation and discard the damaged mitochondria in response to mild mitochondrial stresses. Pathologically, migrasomes are released from podocyte during early podocyte stress and/or damage, from platelets after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from microglia/macrophages of the ischemic brain, and from tumor necrosis factor α (TNFα)-activated endothelial cells (ECs); thus, this newly discovered extracellular vesicle is involved in all these pathological processes. Moreover, migrasomes can modulate the proliferation of cancer cell via lateral transferring mRNA and protein. In this review, we will summarize the biogenesis, release, uptake, and rupture of migrasomes and discuss its biological roles in development, redox signalling, innate immunity and COVID-19, cardio-cerebrovascular diseases, renal diseases, and cancer biology, all of these highlight the importance of migrasomes in modulating body homeostasis and diseases. |
format | Online Article Text |
id | pubmed-9023195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90231952022-04-22 Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases Zhang, Yaxing Guo, Wenhai Bi, Mingmin Liu, Wei Zhou, Lequan Liu, Haimei Yan, Fuman Guan, Li Zhang, Jiongshan Xu, Jinwen Oxid Med Cell Longev Review Article Migrasomes are migration-dependent membrane-bound vesicular structures that contain cellular contents and small vesicles. Migrasomes grow on the tips or intersections of the retraction fibers after cells migrate away. The process of releasing migrasomes into the extracellular space is named as “migracytosis”. After releasing, they can be taken up by the surrounding cells, or rupture and further release their contents into the extracellular environment. Physiologically, migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation and discard the damaged mitochondria in response to mild mitochondrial stresses. Pathologically, migrasomes are released from podocyte during early podocyte stress and/or damage, from platelets after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from microglia/macrophages of the ischemic brain, and from tumor necrosis factor α (TNFα)-activated endothelial cells (ECs); thus, this newly discovered extracellular vesicle is involved in all these pathological processes. Moreover, migrasomes can modulate the proliferation of cancer cell via lateral transferring mRNA and protein. In this review, we will summarize the biogenesis, release, uptake, and rupture of migrasomes and discuss its biological roles in development, redox signalling, innate immunity and COVID-19, cardio-cerebrovascular diseases, renal diseases, and cancer biology, all of these highlight the importance of migrasomes in modulating body homeostasis and diseases. Hindawi 2022-04-14 /pmc/articles/PMC9023195/ /pubmed/35464764 http://dx.doi.org/10.1155/2022/4525778 Text en Copyright © 2022 Yaxing Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Yaxing Guo, Wenhai Bi, Mingmin Liu, Wei Zhou, Lequan Liu, Haimei Yan, Fuman Guan, Li Zhang, Jiongshan Xu, Jinwen Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases |
title | Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases |
title_full | Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases |
title_fullStr | Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases |
title_full_unstemmed | Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases |
title_short | Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases |
title_sort | migrasomes: from biogenesis, release, uptake, rupture to homeostasis and diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023195/ https://www.ncbi.nlm.nih.gov/pubmed/35464764 http://dx.doi.org/10.1155/2022/4525778 |
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