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Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases

Aminoacyl-tRNA synthetases (AARS) translate the genetic code by loading tRNAs with the cognate amino acids. The errors in amino acid recognition are cleared at the AARS editing domain through hydrolysis of misaminoacyl-tRNAs. This ensures faithful protein synthesis and cellular fitness. Using Escher...

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Detalles Bibliográficos
Autores principales:	Zivkovic, Igor, Ivkovic, Kate, Cvetesic, Nevena, Marsavelski, Aleksandra, Gruic-Sovulj, Ita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023258/ https://www.ncbi.nlm.nih.gov/pubmed/35357484 http://dx.doi.org/10.1093/nar/gkac207

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