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Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

Homologous recombination-deficient cancers rely on DNA polymerase Theta (Polθ)-Mediated End Joining (TMEJ), an alternative double-strand break repair pathway. Polθ is the only vertebrate polymerase that encodes an N-terminal superfamily 2 (SF2) helicase domain, but the role of this helicase domain i...

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Detalles Bibliográficos
Autores principales:	Schaub, Jeffrey M, Soniat, Michael M, Finkelstein, Ilya J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023281/ https://www.ncbi.nlm.nih.gov/pubmed/35357490 http://dx.doi.org/10.1093/nar/gkac119

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