How can Biology of Aging Explain the Severity of COVID-19 in Older Adults

Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarco...

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Detalles Bibliográficos
Autores principales: Gallo, Antonella, Pero, Erika, Pellegrino, Simona, Macerola, Noemi, Murace, Celeste Ambra, Ibba, Francesca, Agnitelli, Maria Chiara, Landi, Francesco, Montalto, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023334/
https://www.ncbi.nlm.nih.gov/pubmed/35868666
http://dx.doi.org/10.1016/j.cger.2022.04.002
Descripción
Sumario:Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.

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