How can Biology of Aging Explain the Severity of COVID-19 in Older Adults

Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarco...

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Autores principales: Gallo, Antonella, Pero, Erika, Pellegrino, Simona, Macerola, Noemi, Murace, Celeste Ambra, Ibba, Francesca, Agnitelli, Maria Chiara, Landi, Francesco, Montalto, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023334/
https://www.ncbi.nlm.nih.gov/pubmed/35868666
http://dx.doi.org/10.1016/j.cger.2022.04.002
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author Gallo, Antonella
Pero, Erika
Pellegrino, Simona
Macerola, Noemi
Murace, Celeste Ambra
Ibba, Francesca
Agnitelli, Maria Chiara
Landi, Francesco
Montalto, Massimo
author_facet Gallo, Antonella
Pero, Erika
Pellegrino, Simona
Macerola, Noemi
Murace, Celeste Ambra
Ibba, Francesca
Agnitelli, Maria Chiara
Landi, Francesco
Montalto, Massimo
author_sort Gallo, Antonella
collection PubMed
description Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.
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spelling pubmed-90233342022-04-22 How can Biology of Aging Explain the Severity of COVID-19 in Older Adults Gallo, Antonella Pero, Erika Pellegrino, Simona Macerola, Noemi Murace, Celeste Ambra Ibba, Francesca Agnitelli, Maria Chiara Landi, Francesco Montalto, Massimo Clin Geriatr Med Article Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age. Elsevier Inc. 2022-08 2022-04-22 /pmc/articles/PMC9023334/ /pubmed/35868666 http://dx.doi.org/10.1016/j.cger.2022.04.002 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gallo, Antonella
Pero, Erika
Pellegrino, Simona
Macerola, Noemi
Murace, Celeste Ambra
Ibba, Francesca
Agnitelli, Maria Chiara
Landi, Francesco
Montalto, Massimo
How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
title How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
title_full How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
title_fullStr How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
title_full_unstemmed How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
title_short How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
title_sort how can biology of aging explain the severity of covid-19 in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023334/
https://www.ncbi.nlm.nih.gov/pubmed/35868666
http://dx.doi.org/10.1016/j.cger.2022.04.002
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