USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome pro...

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Detalles Bibliográficos
Autores principales: Ning, Zhen, Guo, Xin, Liu, Xiaolong, Lu, Chang, Wang, Aman, Wang, Xiaolin, Wang, Wen, Chen, Huan, Qin, Wangshu, Liu, Xinyu, Zhou, Lina, Ma, Chi, Du, Jian, Lin, Zhikun, Luo, Haifeng, Otkur, Wuxiyar, Qi, Huan, Chen, Di, Xia, Tian, Liu, Jiwei, Tan, Guang, Xu, Guowang, Piao, Hai-long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023467/
https://www.ncbi.nlm.nih.gov/pubmed/35449157
http://dx.doi.org/10.1038/s41467-022-29846-9

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