Cargando…

Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease

In pursuit of treating Parkinson’s disease with cell replacement therapy, differentiated induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA) cells. We previously established a protocol for differentiating iPSC-derived post-mitotic mDA neurons capable of reversing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hiller, Benjamin M., Marmion, David J., Thompson, Cayla A., Elliott, Nathaniel A., Federoff, Howard, Brundin, Patrik, Mattis, Virginia B., McMahon, Christopher W., Kordower, Jeffrey H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023503/ https://www.ncbi.nlm.nih.gov/pubmed/35449132 http://dx.doi.org/10.1038/s41536-022-00221-y

Ejemplares similares

Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
por: Wakeman, Dustin R., et al.
Publicado: (2017)

Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo
por: Hiller, Benjamin M., et al.
Publicado: (2020)

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
por: Otero, Maria G., et al.
Publicado: (2023)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2023)

Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells
por: Akhtar, Aslam Abbasi, et al.
Publicado: (2018)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?
por: von Linstow, Christian U., et al.
Publicado: (2020)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease
por: Mathkar, Pranav P., et al.
Publicado: (2019)

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
por: Varderidou-Minasian, Suzy, et al.
Publicado: (2020)

Automated high-content imaging in iPSC-derived neuronal progenitors
por: Papandreou, Apostolos, et al.
Publicado: (2023)

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons
por: Beevers, Joel E., et al.
Publicado: (2017)

Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model
por: Wang, Shuyan, et al.
Publicado: (2015)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
por: Zambon, Federico, et al.
Publicado: (2019)

Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells
por: Zhao, Kaixuan, et al.
Publicado: (2022)

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation
por: Kuang, Yu-Lin, et al.
Publicado: (2019)

MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors
por: Giacomazzi, Giorgia, et al.
Publicado: (2017)

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons
por: Emperador Melero, Javier, et al.
Publicado: (2017)

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes
por: Zuppinger, Christian, et al.
Publicado: (2017)

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
por: M. Feyen, Dries A., et al.
Publicado: (2020)

Long-Term Evaluation of Intranigral Transplantation of Human iPSC-Derived Dopamine Neurons in a Parkinson’s Disease Mouse Model
por: Brot, Sébastien, et al.
Publicado: (2022)

Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors
por: Tanigawa, Shunsuke, et al.
Publicado: (2019)

Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation
por: Isoda, Miho, et al.
Publicado: (2023)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation
por: Vethe, Heidrun, et al.
Publicado: (2019)

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
por: Miki, Kenji, et al.
Publicado: (2021)

Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
por: Vučković, Sofija, et al.
Publicado: (2022)

Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes
por: Peters, Marijn C, et al.
Publicado: (2022)

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures
por: Suominen, Siiri, et al.
Publicado: (2023)

Using iPSC‐derived human DA neurons from opioid‐dependent subjects to study dopamine dynamics
por: Sheng, Yang, et al.
Publicado: (2016)

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors
por: Sproul, Andrew A., et al.
Publicado: (2014)

Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1
por: Samata, Bumpei, et al.
Publicado: (2016)

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors
por: Melguizo-Sanchis, Dario, et al.
Publicado: (2018)

Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
por: Chen, Ying, et al.
Publicado: (2017)

Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids
por: Zhang, Ran-Ran, et al.
Publicado: (2018)

Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice
por: Haller, Corinne, et al.
Publicado: (2019)

Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells
por: Gozlan, Sandy, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8m9ivp4o9poditp2km6jsibnah