Mechanism of cancer stemness maintenance in human liver cancer

Primary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA). Recent studies have indicated that there are differences in cancer stem cell (CSC) pr...

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Autores principales: Liang, Ning, Yang, Tao, Huang, Qian, Yu, Pengfei, Liu, Chaoxu, Chen, Liusheng, Wang, Qian, Wang, Gang, He, Xianli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023565/
https://www.ncbi.nlm.nih.gov/pubmed/35449193
http://dx.doi.org/10.1038/s41419-022-04848-z
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author Liang, Ning
Yang, Tao
Huang, Qian
Yu, Pengfei
Liu, Chaoxu
Chen, Liusheng
Wang, Qian
Wang, Gang
He, Xianli
author_facet Liang, Ning
Yang, Tao
Huang, Qian
Yu, Pengfei
Liu, Chaoxu
Chen, Liusheng
Wang, Qian
Wang, Gang
He, Xianli
author_sort Liang, Ning
collection PubMed
description Primary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA). Recent studies have indicated that there are differences in cancer stem cell (CSC) properties among different types of liver cancer. Liver cancer stem cells (LCSCs), also called liver tumor-initiating cells, have been viewed as drivers of tumor initiation and metastasis. Many mechanisms and factors, such as mitophagy, mitochondrial dynamics, epigenetic modifications, the tumor microenvironment, and tumor plasticity, are involved in the regulation of cancer stemness in liver cancer. In this review, we analyze cancer stemness in different liver cancer types. Moreover, we further evaluate the mechanism of cancer stemness maintenance of LCSCs and discuss promising treatments for eradicating LCSCs.
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spelling pubmed-90235652022-04-28 Mechanism of cancer stemness maintenance in human liver cancer Liang, Ning Yang, Tao Huang, Qian Yu, Pengfei Liu, Chaoxu Chen, Liusheng Wang, Qian Wang, Gang He, Xianli Cell Death Dis Review Article Primary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA). Recent studies have indicated that there are differences in cancer stem cell (CSC) properties among different types of liver cancer. Liver cancer stem cells (LCSCs), also called liver tumor-initiating cells, have been viewed as drivers of tumor initiation and metastasis. Many mechanisms and factors, such as mitophagy, mitochondrial dynamics, epigenetic modifications, the tumor microenvironment, and tumor plasticity, are involved in the regulation of cancer stemness in liver cancer. In this review, we analyze cancer stemness in different liver cancer types. Moreover, we further evaluate the mechanism of cancer stemness maintenance of LCSCs and discuss promising treatments for eradicating LCSCs. Nature Publishing Group UK 2022-04-21 /pmc/articles/PMC9023565/ /pubmed/35449193 http://dx.doi.org/10.1038/s41419-022-04848-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Liang, Ning
Yang, Tao
Huang, Qian
Yu, Pengfei
Liu, Chaoxu
Chen, Liusheng
Wang, Qian
Wang, Gang
He, Xianli
Mechanism of cancer stemness maintenance in human liver cancer
title Mechanism of cancer stemness maintenance in human liver cancer
title_full Mechanism of cancer stemness maintenance in human liver cancer
title_fullStr Mechanism of cancer stemness maintenance in human liver cancer
title_full_unstemmed Mechanism of cancer stemness maintenance in human liver cancer
title_short Mechanism of cancer stemness maintenance in human liver cancer
title_sort mechanism of cancer stemness maintenance in human liver cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023565/
https://www.ncbi.nlm.nih.gov/pubmed/35449193
http://dx.doi.org/10.1038/s41419-022-04848-z
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