Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility...

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Detalles Bibliográficos
Autores principales: Shi, Xiaohan, Li, Yunguang, Yuan, Qiuyue, Tang, Shijie, Guo, Shiwei, Zhang, Yehan, He, Juan, Zhang, Xiaoyu, Han, Ming, Liu, Zhuang, Zhu, Yiqin, Gao, Suizhi, Wang, Huan, Xu, Xiongfei, Zheng, Kailian, Jing, Wei, Chen, Luonan, Wang, Yong, Jin, Gang, Gao, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023604/
https://www.ncbi.nlm.nih.gov/pubmed/35449156
http://dx.doi.org/10.1038/s41467-022-29857-6

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