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Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect

The Ras-specific guanine nucleotide exchange factors Son of Sevenless (SOS) regulates Ras activation by converting inactive GDP-bound to active GTP-bound states. The catalytic activity of Ras is further allosterically regulated by GTP−Ras bound to a distal site through a positive feedback loop. To a...

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Detalles Bibliográficos
Autores principales:	He, Xuan, Du, Kui, Wang, Yuanhao, Fan, Jigang, Li, Mingyu, Ni, Duan, Lu, Shaoyong, Bian, Xiaolan, Liu, Yaqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023742/ https://www.ncbi.nlm.nih.gov/pubmed/35463958 http://dx.doi.org/10.3389/fmolb.2022.860962

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