Aging of intestinal stem cells

The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes in the aged crypts. The correspondent decline in the regener...

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Detalles Bibliográficos
Autores principales: Nalapareddy, Kodandaramireddy, Zheng, Yi, Geiger, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023768/
https://www.ncbi.nlm.nih.gov/pubmed/35276089
http://dx.doi.org/10.1016/j.stemcr.2022.02.003
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author Nalapareddy, Kodandaramireddy
Zheng, Yi
Geiger, Hartmut
author_facet Nalapareddy, Kodandaramireddy
Zheng, Yi
Geiger, Hartmut
author_sort Nalapareddy, Kodandaramireddy
collection PubMed
description The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes in the aged crypts. The correspondent decline in the regenerative capacity of the intestine is mainly due to a decline in intestinal stem cell function upon aging, as the underlying mechanisms of aging intestinal stem cells are beginning to unravel. This review summarizes our current knowledge on stem cell-intrinsic mechanisms of aging of intestinal stem cells and their connection to extrinsic factors, such as niche cells and microbiota and will introduce recent approaches to attenuate or even revert the aging of intestinal stem cells.
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spelling pubmed-90237682022-04-23 Aging of intestinal stem cells Nalapareddy, Kodandaramireddy Zheng, Yi Geiger, Hartmut Stem Cell Reports Review The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes in the aged crypts. The correspondent decline in the regenerative capacity of the intestine is mainly due to a decline in intestinal stem cell function upon aging, as the underlying mechanisms of aging intestinal stem cells are beginning to unravel. This review summarizes our current knowledge on stem cell-intrinsic mechanisms of aging of intestinal stem cells and their connection to extrinsic factors, such as niche cells and microbiota and will introduce recent approaches to attenuate or even revert the aging of intestinal stem cells. Elsevier 2022-03-10 /pmc/articles/PMC9023768/ /pubmed/35276089 http://dx.doi.org/10.1016/j.stemcr.2022.02.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Nalapareddy, Kodandaramireddy
Zheng, Yi
Geiger, Hartmut
Aging of intestinal stem cells
title Aging of intestinal stem cells
title_full Aging of intestinal stem cells
title_fullStr Aging of intestinal stem cells
title_full_unstemmed Aging of intestinal stem cells
title_short Aging of intestinal stem cells
title_sort aging of intestinal stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023768/
https://www.ncbi.nlm.nih.gov/pubmed/35276089
http://dx.doi.org/10.1016/j.stemcr.2022.02.003
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