Is hypoimmunogenic stem cell therapy safe in times of pandemics?

The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore,...

Descripción completa

Detalles Bibliográficos
Autores principales: Matheus, Friederike, Raveh, Tal, Oro, Anthony E., Wernig, Marius, Drukker, Micha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023772/
https://www.ncbi.nlm.nih.gov/pubmed/35334219
http://dx.doi.org/10.1016/j.stemcr.2022.02.014
Descripción
Sumario:The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.

Ejemplares similares