Is hypoimmunogenic stem cell therapy safe in times of pandemics?

The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore,...

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Autores principales: Matheus, Friederike, Raveh, Tal, Oro, Anthony E., Wernig, Marius, Drukker, Micha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023772/
https://www.ncbi.nlm.nih.gov/pubmed/35334219
http://dx.doi.org/10.1016/j.stemcr.2022.02.014
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author Matheus, Friederike
Raveh, Tal
Oro, Anthony E.
Wernig, Marius
Drukker, Micha
author_facet Matheus, Friederike
Raveh, Tal
Oro, Anthony E.
Wernig, Marius
Drukker, Micha
author_sort Matheus, Friederike
collection PubMed
description The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
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spelling pubmed-90237722022-04-23 Is hypoimmunogenic stem cell therapy safe in times of pandemics? Matheus, Friederike Raveh, Tal Oro, Anthony E. Wernig, Marius Drukker, Micha Stem Cell Reports Perspective The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies. Elsevier 2022-03-24 /pmc/articles/PMC9023772/ /pubmed/35334219 http://dx.doi.org/10.1016/j.stemcr.2022.02.014 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Matheus, Friederike
Raveh, Tal
Oro, Anthony E.
Wernig, Marius
Drukker, Micha
Is hypoimmunogenic stem cell therapy safe in times of pandemics?
title Is hypoimmunogenic stem cell therapy safe in times of pandemics?
title_full Is hypoimmunogenic stem cell therapy safe in times of pandemics?
title_fullStr Is hypoimmunogenic stem cell therapy safe in times of pandemics?
title_full_unstemmed Is hypoimmunogenic stem cell therapy safe in times of pandemics?
title_short Is hypoimmunogenic stem cell therapy safe in times of pandemics?
title_sort is hypoimmunogenic stem cell therapy safe in times of pandemics?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023772/
https://www.ncbi.nlm.nih.gov/pubmed/35334219
http://dx.doi.org/10.1016/j.stemcr.2022.02.014
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