Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence

Severe ocular surface diseases can lead to limbal stem cell deficiency (LSCD), which is accompanied by defective healing. We aimed to evaluate the role of the substance P (SP)/neurokinin-1 receptor (NK1R) pathway in corneal epithelium wound healing in a pre-clinical model of LSCD. SP ablation or NK1...

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Detalles Bibliográficos
Autores principales: Lasagni Vitar, Romina, Triani, Francesca, Barbariga, Marco, Fonteyne, Philippe, Rama, Paolo, Ferrari, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023781/
https://www.ncbi.nlm.nih.gov/pubmed/35334220
http://dx.doi.org/10.1016/j.stemcr.2022.02.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023781/
https://www.ncbi.nlm.nih.gov/pubmed/35334220
http://dx.doi.org/10.1016/j.stemcr.2022.02.012

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