Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus

Adoptive therapies with genetically modified somatic T cells rendered HIV resistance have shown promise for AIDS therapy. A renewable source of HIV-resistant human T cells from induced pluripotent stem cells (iPSCs) would further facilitate and broaden the applicability of these therapies. Here, we...

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Detalles Bibliográficos
Autores principales: D’Souza, Saritha S., Kumar, Akhilesh, Weinfurter, Jason, Park, Mi Ae, Maufort, John, Tao, Lihong, Kang, HyunJun, Dettle, Samuel T., Golos, Thaddeus, Thomson, James A., Reynolds, Matthew R., Slukvin, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023799/
https://www.ncbi.nlm.nih.gov/pubmed/35364011
http://dx.doi.org/10.1016/j.stemcr.2022.03.003

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