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The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion
Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It is widely thought that the impairment of decidualization is in...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023862/ https://www.ncbi.nlm.nih.gov/pubmed/35465321 http://dx.doi.org/10.3389/fcell.2022.862180 |
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author | Zhu, Rong-hui Dai, Fang-fang Yang, Dong-yong Liu, Shi-yi Zheng, Ya-jing Wu, Ma-li Deng, Zhi-min Wang, Zi-tao Zhang, Yu-wei Tan, Wei Li, Zhi-dian He, Juan Yang, Xiao Hu, Min Cheng, Yan-xiang |
author_facet | Zhu, Rong-hui Dai, Fang-fang Yang, Dong-yong Liu, Shi-yi Zheng, Ya-jing Wu, Ma-li Deng, Zhi-min Wang, Zi-tao Zhang, Yu-wei Tan, Wei Li, Zhi-dian He, Juan Yang, Xiao Hu, Min Cheng, Yan-xiang |
author_sort | Zhu, Rong-hui |
collection | PubMed |
description | Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It is widely thought that the impairment of decidualization is inclined to induce subsequent pregnancy failure and leads to the dysregulation of extra-villous trophoblast invasion and proliferation through maternal–fetal cross talk. However, the mechanism of decidualization in RSA has yet to be understood. In our study, we demonstrate that decidual samples from RSA patients have significantly higher insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and lower TGF-β1 levels compared to healthy controls. In addition, the overexpression of IGF2BP3 in human endometrial stromal cells (hESCs) can lead to the impairment of decidualization in vitro-induced model and the abnormal cell cycle regulation. Furthermore, TGF-β1 and MMP9 levels were greatly increased after decidualization, whereas IGF2BP3 overexpression inhibited endometrial mesenchymal decidualization by downregulating TGF-β1, impeding maternal–fetal interface cytokine cross talk, and limiting the ability of trophoblast invasion. In conclusion, our investigation first demonstrates that abnormal elevation of IGF2BP3 in the pregnant endometrium leads to the impairment of decidualization and abnormal trophoblast invasion, thereby predisposing individuals to RSA. |
format | Online Article Text |
id | pubmed-9023862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90238622022-04-23 The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion Zhu, Rong-hui Dai, Fang-fang Yang, Dong-yong Liu, Shi-yi Zheng, Ya-jing Wu, Ma-li Deng, Zhi-min Wang, Zi-tao Zhang, Yu-wei Tan, Wei Li, Zhi-dian He, Juan Yang, Xiao Hu, Min Cheng, Yan-xiang Front Cell Dev Biol Cell and Developmental Biology Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It is widely thought that the impairment of decidualization is inclined to induce subsequent pregnancy failure and leads to the dysregulation of extra-villous trophoblast invasion and proliferation through maternal–fetal cross talk. However, the mechanism of decidualization in RSA has yet to be understood. In our study, we demonstrate that decidual samples from RSA patients have significantly higher insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and lower TGF-β1 levels compared to healthy controls. In addition, the overexpression of IGF2BP3 in human endometrial stromal cells (hESCs) can lead to the impairment of decidualization in vitro-induced model and the abnormal cell cycle regulation. Furthermore, TGF-β1 and MMP9 levels were greatly increased after decidualization, whereas IGF2BP3 overexpression inhibited endometrial mesenchymal decidualization by downregulating TGF-β1, impeding maternal–fetal interface cytokine cross talk, and limiting the ability of trophoblast invasion. In conclusion, our investigation first demonstrates that abnormal elevation of IGF2BP3 in the pregnant endometrium leads to the impairment of decidualization and abnormal trophoblast invasion, thereby predisposing individuals to RSA. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9023862/ /pubmed/35465321 http://dx.doi.org/10.3389/fcell.2022.862180 Text en Copyright © 2022 Zhu, Dai, Yang, Liu, Zheng, Wu, Deng, Wang, Zhang, Tan, Li, He, Yang, Hu and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhu, Rong-hui Dai, Fang-fang Yang, Dong-yong Liu, Shi-yi Zheng, Ya-jing Wu, Ma-li Deng, Zhi-min Wang, Zi-tao Zhang, Yu-wei Tan, Wei Li, Zhi-dian He, Juan Yang, Xiao Hu, Min Cheng, Yan-xiang The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
title | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
title_full | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
title_fullStr | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
title_full_unstemmed | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
title_short | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
title_sort | mechanism of insulin-like growth factor ii mrna-binging protein 3 induce decidualization and maternal-fetal interface cross talk by tgf-β1 in recurrent spontaneous abortion |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023862/ https://www.ncbi.nlm.nih.gov/pubmed/35465321 http://dx.doi.org/10.3389/fcell.2022.862180 |
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