Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care

Testicular cancer is the most common solid tumor affecting young males. Most testicular cancers are testicular germ cell tumors (TGCTs), which are divided into seminomas (SGCTs) and non-seminomatous testicular germ cell tumors (NSGCTs). During their development, primordial germ cells (PGCs) undergo...

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Autores principales: Nicu, Alina-Teodora, Medar, Cosmin, Chifiriuc, Mariana Carmen, Gradisteanu Pircalabioru, Gratiela, Burlibasa, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023878/
https://www.ncbi.nlm.nih.gov/pubmed/35465311
http://dx.doi.org/10.3389/fcell.2022.861995
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author Nicu, Alina-Teodora
Medar, Cosmin
Chifiriuc, Mariana Carmen
Gradisteanu Pircalabioru, Gratiela
Burlibasa, Liliana
author_facet Nicu, Alina-Teodora
Medar, Cosmin
Chifiriuc, Mariana Carmen
Gradisteanu Pircalabioru, Gratiela
Burlibasa, Liliana
author_sort Nicu, Alina-Teodora
collection PubMed
description Testicular cancer is the most common solid tumor affecting young males. Most testicular cancers are testicular germ cell tumors (TGCTs), which are divided into seminomas (SGCTs) and non-seminomatous testicular germ cell tumors (NSGCTs). During their development, primordial germ cells (PGCs) undergo epigenetic modifications and any disturbances in their pattern might lead to cancer development. The present study provides a comprehensive review of the epigenetic mechanisms–DNA methylation, histone post-translational modifications, bivalent marks, non-coding RNA–associated with TGCT susceptibility, initiation, progression and response to chemotherapy. Another important purpose of this review is to highlight the recent investigations regarding the identification and development of epigenetic biomarkers as powerful tools for the diagnostic, prognostic and especially for epigenetic-based therapy.
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spelling pubmed-90238782022-04-23 Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care Nicu, Alina-Teodora Medar, Cosmin Chifiriuc, Mariana Carmen Gradisteanu Pircalabioru, Gratiela Burlibasa, Liliana Front Cell Dev Biol Cell and Developmental Biology Testicular cancer is the most common solid tumor affecting young males. Most testicular cancers are testicular germ cell tumors (TGCTs), which are divided into seminomas (SGCTs) and non-seminomatous testicular germ cell tumors (NSGCTs). During their development, primordial germ cells (PGCs) undergo epigenetic modifications and any disturbances in their pattern might lead to cancer development. The present study provides a comprehensive review of the epigenetic mechanisms–DNA methylation, histone post-translational modifications, bivalent marks, non-coding RNA–associated with TGCT susceptibility, initiation, progression and response to chemotherapy. Another important purpose of this review is to highlight the recent investigations regarding the identification and development of epigenetic biomarkers as powerful tools for the diagnostic, prognostic and especially for epigenetic-based therapy. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9023878/ /pubmed/35465311 http://dx.doi.org/10.3389/fcell.2022.861995 Text en Copyright © 2022 Nicu, Medar, Chifiriuc, Gradisteanu Pircalabioru and Burlibasa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Nicu, Alina-Teodora
Medar, Cosmin
Chifiriuc, Mariana Carmen
Gradisteanu Pircalabioru, Gratiela
Burlibasa, Liliana
Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
title Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
title_full Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
title_fullStr Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
title_full_unstemmed Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
title_short Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
title_sort epigenetics and testicular cancer: bridging the gap between fundamental biology and patient care
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023878/
https://www.ncbi.nlm.nih.gov/pubmed/35465311
http://dx.doi.org/10.3389/fcell.2022.861995
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