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Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty

PURPOSE: To examine the utilization patterns of cornea procured from diseased individuals ≥75 years of age at an eye bank in western India. METHODS: In this retrospective study, data from 1,217 eyes of 653 donors with age ≥75 years were reviewed from October 2008 to December 2019. Donor age, lens st...

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Autores principales: Shah, Rakesh, Hirwe, Supriya, Ashar, Jatin, Sengupta, Sabyasachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023935/
https://www.ncbi.nlm.nih.gov/pubmed/35086227
http://dx.doi.org/10.4103/ijo.IJO_1329_21
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author Shah, Rakesh
Hirwe, Supriya
Ashar, Jatin
Sengupta, Sabyasachi
author_facet Shah, Rakesh
Hirwe, Supriya
Ashar, Jatin
Sengupta, Sabyasachi
author_sort Shah, Rakesh
collection PubMed
description PURPOSE: To examine the utilization patterns of cornea procured from diseased individuals ≥75 years of age at an eye bank in western India. METHODS: In this retrospective study, data from 1,217 eyes of 653 donors with age ≥75 years were reviewed from October 2008 to December 2019. Donor age, lens status, endothelial cell count (ECD), utilization of the tissue for transplantation or non-clinical purposes (e.g., research, training/discarded), and causes of non-utilization were noted. RESULTS: The mean age of the donors was 80.9 ± 4.6 years and the tissue utilization rate was 36.5% (445 out of 1,217 eyes). The eyes used for keratoplasty procedures had a lower donor age (79.6 ± 5.7 vs. 81.5 ± 5.1; P < 0.001), a higher endothelial cell count (2493 ± 531 vs. 2034 ± 581; P < 0.001), and were more often phakic (61% vs. 36.6%) compared to the unused group. A multivariable logistic regression analysis showed that the likelihood of tissue utilization for keratoplasty was 13% higher with every 100-cell increment in donor ECD (odds ratio [OR] = 1.13, 95% CI = 1.10–1.16, P < 0.001) and 33% lower with having a pseudophakic status in the donor eye (OR = 0.67, 95% CI = 0.52–0.87, P = 0.03). Age was not a significant determinant of tissue utilization when used in the same multivariable model. CONCLUSION: More than one-third of the eyes (36.5%) can be utilized even when the donors are above 75 years of age. Eyes that were more likely to be utilized for keratoplasty were phakic and had a significantly higher ECD; age was not a determinant in tissue utilization.
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spelling pubmed-90239352022-04-23 Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty Shah, Rakesh Hirwe, Supriya Ashar, Jatin Sengupta, Sabyasachi Indian J Ophthalmol Special Focus, Cornea, Original Article PURPOSE: To examine the utilization patterns of cornea procured from diseased individuals ≥75 years of age at an eye bank in western India. METHODS: In this retrospective study, data from 1,217 eyes of 653 donors with age ≥75 years were reviewed from October 2008 to December 2019. Donor age, lens status, endothelial cell count (ECD), utilization of the tissue for transplantation or non-clinical purposes (e.g., research, training/discarded), and causes of non-utilization were noted. RESULTS: The mean age of the donors was 80.9 ± 4.6 years and the tissue utilization rate was 36.5% (445 out of 1,217 eyes). The eyes used for keratoplasty procedures had a lower donor age (79.6 ± 5.7 vs. 81.5 ± 5.1; P < 0.001), a higher endothelial cell count (2493 ± 531 vs. 2034 ± 581; P < 0.001), and were more often phakic (61% vs. 36.6%) compared to the unused group. A multivariable logistic regression analysis showed that the likelihood of tissue utilization for keratoplasty was 13% higher with every 100-cell increment in donor ECD (odds ratio [OR] = 1.13, 95% CI = 1.10–1.16, P < 0.001) and 33% lower with having a pseudophakic status in the donor eye (OR = 0.67, 95% CI = 0.52–0.87, P = 0.03). Age was not a significant determinant of tissue utilization when used in the same multivariable model. CONCLUSION: More than one-third of the eyes (36.5%) can be utilized even when the donors are above 75 years of age. Eyes that were more likely to be utilized for keratoplasty were phakic and had a significantly higher ECD; age was not a determinant in tissue utilization. Wolters Kluwer - Medknow 2022-02 2022-01-27 /pmc/articles/PMC9023935/ /pubmed/35086227 http://dx.doi.org/10.4103/ijo.IJO_1329_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Special Focus, Cornea, Original Article
Shah, Rakesh
Hirwe, Supriya
Ashar, Jatin
Sengupta, Sabyasachi
Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty
title Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty
title_full Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty
title_fullStr Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty
title_full_unstemmed Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty
title_short Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty
title_sort utilization rate of corneal tissue obtained from donors over 75 years of age in western india for keratoplasty
topic Special Focus, Cornea, Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023935/
https://www.ncbi.nlm.nih.gov/pubmed/35086227
http://dx.doi.org/10.4103/ijo.IJO_1329_21
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