A modified model of glaucoma filtering surgery in Sprague-Dawley rats

Animal models are useful in glaucoma research to study tissue response to wound healing. Smaller animals such as rats offer additional advantages in terms of availability of detection antibodies and microarrays with cheaper maintenance costs. In this study, we describe a glaucoma filtering surgery (...

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Autores principales: Pandav, Surinder Singh, Akella, Madhuri, Thattaruthody, Faisal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Surgical Technique
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023942/
https://www.ncbi.nlm.nih.gov/pubmed/35086259
http://dx.doi.org/10.4103/ijo.IJO_2037_21
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author Pandav, Surinder Singh
Akella, Madhuri
Thattaruthody, Faisal
author_facet Pandav, Surinder Singh
Akella, Madhuri
Thattaruthody, Faisal
author_sort Pandav, Surinder Singh
collection PubMed
description Animal models are useful in glaucoma research to study tissue response to wound healing. Smaller animals such as rats offer additional advantages in terms of availability of detection antibodies and microarrays with cheaper maintenance costs. In this study, we describe a glaucoma filtering surgery (GFS) model in adult Sprague–Dawley rats by performing a sclerostomy using a 26-G needle and additionally placing a silicone tube (27 G) connecting the anterior chamber to the subconjunctival space to maintain a patent fistula for the flow of aqueous humor, thus providing a more definitive bleb. This technique will be useful in identifying and modifying newer targets in the wound healing process in order to improve surgical outcomes following GFS.
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spelling pubmed-90239422022-04-23 A modified model of glaucoma filtering surgery in Sprague-Dawley rats Pandav, Surinder Singh Akella, Madhuri Thattaruthody, Faisal Indian J Ophthalmol Surgical Technique Animal models are useful in glaucoma research to study tissue response to wound healing. Smaller animals such as rats offer additional advantages in terms of availability of detection antibodies and microarrays with cheaper maintenance costs. In this study, we describe a glaucoma filtering surgery (GFS) model in adult Sprague–Dawley rats by performing a sclerostomy using a 26-G needle and additionally placing a silicone tube (27 G) connecting the anterior chamber to the subconjunctival space to maintain a patent fistula for the flow of aqueous humor, thus providing a more definitive bleb. This technique will be useful in identifying and modifying newer targets in the wound healing process in order to improve surgical outcomes following GFS. Wolters Kluwer - Medknow 2022-02 2022-01-27 /pmc/articles/PMC9023942/ /pubmed/35086259 http://dx.doi.org/10.4103/ijo.IJO_2037_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Surgical Technique
Pandav, Surinder Singh
Akella, Madhuri
Thattaruthody, Faisal
A modified model of glaucoma filtering surgery in Sprague-Dawley rats
title A modified model of glaucoma filtering surgery in Sprague-Dawley rats
title_full A modified model of glaucoma filtering surgery in Sprague-Dawley rats
title_fullStr A modified model of glaucoma filtering surgery in Sprague-Dawley rats
title_full_unstemmed A modified model of glaucoma filtering surgery in Sprague-Dawley rats
title_short A modified model of glaucoma filtering surgery in Sprague-Dawley rats
title_sort modified model of glaucoma filtering surgery in sprague-dawley rats
topic Surgical Technique
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023942/
https://www.ncbi.nlm.nih.gov/pubmed/35086259
http://dx.doi.org/10.4103/ijo.IJO_2037_21
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