Cargando…
The Microbiome in Periodontitis and Diabetes
OBJECTIVES: To perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease. MATERIALS AND METHODS: The review was conducted by two independent reviewers. Indexed el...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024052/ https://www.ncbi.nlm.nih.gov/pubmed/35464780 http://dx.doi.org/10.3389/froh.2022.859209 |
_version_ | 1784690481263804416 |
---|---|
author | Silva, Davi Neto de Araújo Casarin, Maísa Monajemzadeh, Sepehr Bezerra, Beatriz de Brito Lux, Renate Pirih, Flavia Q. |
author_facet | Silva, Davi Neto de Araújo Casarin, Maísa Monajemzadeh, Sepehr Bezerra, Beatriz de Brito Lux, Renate Pirih, Flavia Q. |
author_sort | Silva, Davi Neto de Araújo |
collection | PubMed |
description | OBJECTIVES: To perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease. MATERIALS AND METHODS: The review was conducted by two independent reviewers. Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science and Scopus) were searched, including articles published in English and dated from 5 years ago until December 2021. A manual search also was performed to identify co-related articles. Following the removal of duplicates and eligibility criteria, the articles were included in tables for analysis and described in the manuscript. RESULTS: According to this review, diabetes mellitus was associated with significant changes in the subgingival and salivary microbiome, either in its association with periodontitis or in cases of periodontal health. In addition to affecting microbial diversity in terms of taxonomy, metagenomic studies have shown that this endocrine disorder may also be directly related to increased pathogenicity in the oral microbiome. CONCLUSION: Although the reviewed studies demonstrate important differences in the subgingival and salivary microbiome composition because of diabetes mellitus, further studies are needed to clarify the real effects of hyperglycemia on oral microbial profiles and support new diagnostic approaches and innovative treatments. |
format | Online Article Text |
id | pubmed-9024052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90240522022-04-23 The Microbiome in Periodontitis and Diabetes Silva, Davi Neto de Araújo Casarin, Maísa Monajemzadeh, Sepehr Bezerra, Beatriz de Brito Lux, Renate Pirih, Flavia Q. Front Oral Health Oral Health OBJECTIVES: To perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease. MATERIALS AND METHODS: The review was conducted by two independent reviewers. Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science and Scopus) were searched, including articles published in English and dated from 5 years ago until December 2021. A manual search also was performed to identify co-related articles. Following the removal of duplicates and eligibility criteria, the articles were included in tables for analysis and described in the manuscript. RESULTS: According to this review, diabetes mellitus was associated with significant changes in the subgingival and salivary microbiome, either in its association with periodontitis or in cases of periodontal health. In addition to affecting microbial diversity in terms of taxonomy, metagenomic studies have shown that this endocrine disorder may also be directly related to increased pathogenicity in the oral microbiome. CONCLUSION: Although the reviewed studies demonstrate important differences in the subgingival and salivary microbiome composition because of diabetes mellitus, further studies are needed to clarify the real effects of hyperglycemia on oral microbial profiles and support new diagnostic approaches and innovative treatments. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9024052/ /pubmed/35464780 http://dx.doi.org/10.3389/froh.2022.859209 Text en Copyright © 2022 Silva, Casarin, Monajemzadeh, Bezerra, Lux and Pirih. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oral Health Silva, Davi Neto de Araújo Casarin, Maísa Monajemzadeh, Sepehr Bezerra, Beatriz de Brito Lux, Renate Pirih, Flavia Q. The Microbiome in Periodontitis and Diabetes |
title | The Microbiome in Periodontitis and Diabetes |
title_full | The Microbiome in Periodontitis and Diabetes |
title_fullStr | The Microbiome in Periodontitis and Diabetes |
title_full_unstemmed | The Microbiome in Periodontitis and Diabetes |
title_short | The Microbiome in Periodontitis and Diabetes |
title_sort | microbiome in periodontitis and diabetes |
topic | Oral Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024052/ https://www.ncbi.nlm.nih.gov/pubmed/35464780 http://dx.doi.org/10.3389/froh.2022.859209 |
work_keys_str_mv | AT silvadavinetodearaujo themicrobiomeinperiodontitisanddiabetes AT casarinmaisa themicrobiomeinperiodontitisanddiabetes AT monajemzadehsepehr themicrobiomeinperiodontitisanddiabetes AT bezerrabeatrizdebrito themicrobiomeinperiodontitisanddiabetes AT luxrenate themicrobiomeinperiodontitisanddiabetes AT pirihflaviaq themicrobiomeinperiodontitisanddiabetes AT silvadavinetodearaujo microbiomeinperiodontitisanddiabetes AT casarinmaisa microbiomeinperiodontitisanddiabetes AT monajemzadehsepehr microbiomeinperiodontitisanddiabetes AT bezerrabeatrizdebrito microbiomeinperiodontitisanddiabetes AT luxrenate microbiomeinperiodontitisanddiabetes AT pirihflaviaq microbiomeinperiodontitisanddiabetes |