Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers

Hepatocellular carcinoma (HCC) is a group of highly lethal malignant tumors that seriously threaten human health. The main way to improve the survival quality and reduce the mortality of HCC is early diagnosis and treatment. Therefore, it will be of great significance to explore new quantitative det...

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Autores principales: Liang, Ying, Xu, Yuan, Tong, Yaoyao, Chen, Yue, Chen, Xilu, Wu, Shimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024117/
https://www.ncbi.nlm.nih.gov/pubmed/35464224
http://dx.doi.org/10.3389/fchem.2022.883627
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author Liang, Ying
Xu, Yuan
Tong, Yaoyao
Chen, Yue
Chen, Xilu
Wu, Shimin
author_facet Liang, Ying
Xu, Yuan
Tong, Yaoyao
Chen, Yue
Chen, Xilu
Wu, Shimin
author_sort Liang, Ying
collection PubMed
description Hepatocellular carcinoma (HCC) is a group of highly lethal malignant tumors that seriously threaten human health. The main way to improve the survival quality and reduce the mortality of HCC is early diagnosis and treatment. Therefore, it will be of great significance to explore new quantitative detection methods for HCC markers. With the rapid development of electrochemical biosensors and nanomaterials, electrochemical sensors based on graphene can detect tumor markers, with the advantages of simple operation, high detection sensitivity, and specificity. Combined with the published literature in recent years, the article briefly reviews the application of graphene-based electrochemical biosensors in the detection of HCC markers, including alpha-fetoprotein (AFP), Golgi protein-73 (GP73), exosomes, and microRNA-122 (miR-122).
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spelling pubmed-90241172022-04-23 Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers Liang, Ying Xu, Yuan Tong, Yaoyao Chen, Yue Chen, Xilu Wu, Shimin Front Chem Chemistry Hepatocellular carcinoma (HCC) is a group of highly lethal malignant tumors that seriously threaten human health. The main way to improve the survival quality and reduce the mortality of HCC is early diagnosis and treatment. Therefore, it will be of great significance to explore new quantitative detection methods for HCC markers. With the rapid development of electrochemical biosensors and nanomaterials, electrochemical sensors based on graphene can detect tumor markers, with the advantages of simple operation, high detection sensitivity, and specificity. Combined with the published literature in recent years, the article briefly reviews the application of graphene-based electrochemical biosensors in the detection of HCC markers, including alpha-fetoprotein (AFP), Golgi protein-73 (GP73), exosomes, and microRNA-122 (miR-122). Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9024117/ /pubmed/35464224 http://dx.doi.org/10.3389/fchem.2022.883627 Text en Copyright © 2022 Liang, Xu, Tong, Chen, Chen and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Liang, Ying
Xu, Yuan
Tong, Yaoyao
Chen, Yue
Chen, Xilu
Wu, Shimin
Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers
title Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers
title_full Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers
title_fullStr Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers
title_full_unstemmed Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers
title_short Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers
title_sort graphene-based electrochemical sensor for detection of hepatocellular carcinoma markers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024117/
https://www.ncbi.nlm.nih.gov/pubmed/35464224
http://dx.doi.org/10.3389/fchem.2022.883627
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