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Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol

OBJECTIVE: To explore the predictors for syncopal recurrence in a pediatric population with vasovagal syncope (VVS) treated with metoprolol. STUDY DESIGN: This study was conducted retrospectively among children suffering from VVS with or without syncopal recurrence. Data on the detailed medical hist...

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Autores principales: Tao, Chunyan, Xu, Bowen, Liao, Ying, Li, Xueying, Jin, Hongfang, Du, Junbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024146/
https://www.ncbi.nlm.nih.gov/pubmed/35463909
http://dx.doi.org/10.3389/fped.2022.870939
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author Tao, Chunyan
Xu, Bowen
Liao, Ying
Li, Xueying
Jin, Hongfang
Du, Junbao
author_facet Tao, Chunyan
Xu, Bowen
Liao, Ying
Li, Xueying
Jin, Hongfang
Du, Junbao
author_sort Tao, Chunyan
collection PubMed
description OBJECTIVE: To explore the predictors for syncopal recurrence in a pediatric population with vasovagal syncope (VVS) treated with metoprolol. STUDY DESIGN: This study was conducted retrospectively among children suffering from VVS with or without syncopal recurrence. Data on the detailed medical history and auxiliary examinations were obtained from the electronic medical records. The risk factors for syncopal recurrence were studied by cox regression analyses and the corresponding best cutoff values were determined using receiver operating characteristic analysis. Kaplan–Meier curves were plotted to determine the trends of the syncopal recurrence-free survival rate. RESULTS: Forty-two consecutive VVS children were enrolled in the study. At the end of a median follow-up duration of 9.0 (4.8, 19.1) months, 12 patients (29%) experienced ≥1 syncopal episode. Cox regression analyses revealed that the number of previous syncopal episodes before treatment was a risk factor for syncopal recurrence (hazard ratio = 1.027, 95% confidence interval 1.009 – 1.045, P = 0.003). Moreover, 4 previous syncopal episodes were certified as the best cutoff value, and the Kaplan–Meier curves showed that the syncopal recurrence-free survival rate over time in patients with > 4 previous syncopal episodes was significantly lower than that in patients with ≤4 episodes (P = 0.019 at the log-rank test). CONCLUSION: In a pediatric population with VVS while on the treatment of metoprolol, the number of previous syncopal episodes before treatment played a significant role in predicting syncopal recurrence.
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spelling pubmed-90241462022-04-23 Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol Tao, Chunyan Xu, Bowen Liao, Ying Li, Xueying Jin, Hongfang Du, Junbao Front Pediatr Pediatrics OBJECTIVE: To explore the predictors for syncopal recurrence in a pediatric population with vasovagal syncope (VVS) treated with metoprolol. STUDY DESIGN: This study was conducted retrospectively among children suffering from VVS with or without syncopal recurrence. Data on the detailed medical history and auxiliary examinations were obtained from the electronic medical records. The risk factors for syncopal recurrence were studied by cox regression analyses and the corresponding best cutoff values were determined using receiver operating characteristic analysis. Kaplan–Meier curves were plotted to determine the trends of the syncopal recurrence-free survival rate. RESULTS: Forty-two consecutive VVS children were enrolled in the study. At the end of a median follow-up duration of 9.0 (4.8, 19.1) months, 12 patients (29%) experienced ≥1 syncopal episode. Cox regression analyses revealed that the number of previous syncopal episodes before treatment was a risk factor for syncopal recurrence (hazard ratio = 1.027, 95% confidence interval 1.009 – 1.045, P = 0.003). Moreover, 4 previous syncopal episodes were certified as the best cutoff value, and the Kaplan–Meier curves showed that the syncopal recurrence-free survival rate over time in patients with > 4 previous syncopal episodes was significantly lower than that in patients with ≤4 episodes (P = 0.019 at the log-rank test). CONCLUSION: In a pediatric population with VVS while on the treatment of metoprolol, the number of previous syncopal episodes before treatment played a significant role in predicting syncopal recurrence. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9024146/ /pubmed/35463909 http://dx.doi.org/10.3389/fped.2022.870939 Text en Copyright © 2022 Tao, Xu, Liao, Li, Jin and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Tao, Chunyan
Xu, Bowen
Liao, Ying
Li, Xueying
Jin, Hongfang
Du, Junbao
Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol
title Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol
title_full Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol
title_fullStr Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol
title_full_unstemmed Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol
title_short Predictor of Syncopal Recurrence in Children With Vasovagal Syncope Treated With Metoprolol
title_sort predictor of syncopal recurrence in children with vasovagal syncope treated with metoprolol
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024146/
https://www.ncbi.nlm.nih.gov/pubmed/35463909
http://dx.doi.org/10.3389/fped.2022.870939
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