Intradermal fractional-dose inactivated polio vaccine (fIPV) adjuvanted with double mutant Enterotoxigenic Escherichia coli heat labile toxin (dmLT) is well-tolerated and augments a systemic immune response to all three poliovirus serotypes in a randomized placebo-controlled trial

Eradication of poliomyelitis globally is constrained by fecal shedding of live polioviruses, both wild-type and vaccine-derived strains, into the environment. Although inactivated polio vaccines (IPV) effectively protect the recipient from clinical poliomyelitis, fecal shedding of live virus still o...

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Detalles Bibliográficos
Autores principales: Crothers, Jessica W., Ross Colgate, Elizabeth, Cowan, Kelly J., Dickson, Dorothy M., Walsh, MaryClaire, Carmolli, Marya, Wright, Peter F., Norton, Elizabeth B., Kirkpatrick, Beth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024222/
https://www.ncbi.nlm.nih.gov/pubmed/35367069
http://dx.doi.org/10.1016/j.vaccine.2022.03.056

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