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Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024248/ https://www.ncbi.nlm.nih.gov/pubmed/35463874 http://dx.doi.org/10.3389/fped.2022.856630 |
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author | Oomen, Loes Bootsma-Robroeks, Charlotte Cornelissen, Elisabeth de Wall, Liesbeth Feitz, Wout |
author_facet | Oomen, Loes Bootsma-Robroeks, Charlotte Cornelissen, Elisabeth de Wall, Liesbeth Feitz, Wout |
author_sort | Oomen, Loes |
collection | PubMed |
description | Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients. |
format | Online Article Text |
id | pubmed-9024248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90242482022-04-23 Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades Oomen, Loes Bootsma-Robroeks, Charlotte Cornelissen, Elisabeth de Wall, Liesbeth Feitz, Wout Front Pediatr Pediatrics Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9024248/ /pubmed/35463874 http://dx.doi.org/10.3389/fped.2022.856630 Text en Copyright © 2022 Oomen, Bootsma-Robroeks, Cornelissen, Wall and Feitz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Oomen, Loes Bootsma-Robroeks, Charlotte Cornelissen, Elisabeth de Wall, Liesbeth Feitz, Wout Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades |
title | Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades |
title_full | Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades |
title_fullStr | Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades |
title_full_unstemmed | Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades |
title_short | Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades |
title_sort | pearls and pitfalls in pediatric kidney transplantation after 5 decades |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024248/ https://www.ncbi.nlm.nih.gov/pubmed/35463874 http://dx.doi.org/10.3389/fped.2022.856630 |
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