Cargando…

Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades

Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Oomen, Loes, Bootsma-Robroeks, Charlotte, Cornelissen, Elisabeth, de Wall, Liesbeth, Feitz, Wout
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024248/
https://www.ncbi.nlm.nih.gov/pubmed/35463874
http://dx.doi.org/10.3389/fped.2022.856630
_version_ 1784690534874349568
author Oomen, Loes
Bootsma-Robroeks, Charlotte
Cornelissen, Elisabeth
de Wall, Liesbeth
Feitz, Wout
author_facet Oomen, Loes
Bootsma-Robroeks, Charlotte
Cornelissen, Elisabeth
de Wall, Liesbeth
Feitz, Wout
author_sort Oomen, Loes
collection PubMed
description Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients.
format Online
Article
Text
id pubmed-9024248
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90242482022-04-23 Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades Oomen, Loes Bootsma-Robroeks, Charlotte Cornelissen, Elisabeth de Wall, Liesbeth Feitz, Wout Front Pediatr Pediatrics Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9024248/ /pubmed/35463874 http://dx.doi.org/10.3389/fped.2022.856630 Text en Copyright © 2022 Oomen, Bootsma-Robroeks, Cornelissen, Wall and Feitz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Oomen, Loes
Bootsma-Robroeks, Charlotte
Cornelissen, Elisabeth
de Wall, Liesbeth
Feitz, Wout
Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
title Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
title_full Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
title_fullStr Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
title_full_unstemmed Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
title_short Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
title_sort pearls and pitfalls in pediatric kidney transplantation after 5 decades
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024248/
https://www.ncbi.nlm.nih.gov/pubmed/35463874
http://dx.doi.org/10.3389/fped.2022.856630
work_keys_str_mv AT oomenloes pearlsandpitfallsinpediatrickidneytransplantationafter5decades
AT bootsmarobroekscharlotte pearlsandpitfallsinpediatrickidneytransplantationafter5decades
AT cornelissenelisabeth pearlsandpitfallsinpediatrickidneytransplantationafter5decades
AT dewallliesbeth pearlsandpitfallsinpediatrickidneytransplantationafter5decades
AT feitzwout pearlsandpitfallsinpediatrickidneytransplantationafter5decades