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Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study

The aim of this study was to understand the epidemiology, disease severity, and microbiology of bronchiolitis in Italy during the 2021–2022 cold season, outside of lockdowns. Before COVID-19, the usual bronchiolitis season in Italy would begin in November and end in April, peaking in February. We pe...

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Autores principales: Camporesi, Anna, Morello, Rosa, Ferro, Valentina, Pierantoni, Luca, Rocca, Alessandro, Lanari, Marcello, Trobia, Gian Luca, Sciacca, Tiziana, Bellinvia, Agata Giuseppina, De Ferrari, Alessandra, Valentini, Piero, Roland, Damian, Buonsenso, Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024462/
https://www.ncbi.nlm.nih.gov/pubmed/35455535
http://dx.doi.org/10.3390/children9040491
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author Camporesi, Anna
Morello, Rosa
Ferro, Valentina
Pierantoni, Luca
Rocca, Alessandro
Lanari, Marcello
Trobia, Gian Luca
Sciacca, Tiziana
Bellinvia, Agata Giuseppina
De Ferrari, Alessandra
Valentini, Piero
Roland, Damian
Buonsenso, Danilo
author_facet Camporesi, Anna
Morello, Rosa
Ferro, Valentina
Pierantoni, Luca
Rocca, Alessandro
Lanari, Marcello
Trobia, Gian Luca
Sciacca, Tiziana
Bellinvia, Agata Giuseppina
De Ferrari, Alessandra
Valentini, Piero
Roland, Damian
Buonsenso, Danilo
author_sort Camporesi, Anna
collection PubMed
description The aim of this study was to understand the epidemiology, disease severity, and microbiology of bronchiolitis in Italy during the 2021–2022 cold season, outside of lockdowns. Before COVID-19, the usual bronchiolitis season in Italy would begin in November and end in April, peaking in February. We performed a prospective observational study in four referral pediatric centers located in different geographical areas in Italy (two in the north, one in the center and one in the south). From 1 July 2021 to 31 January 2022, we collected all new clinical diagnoses of bronchiolitis in children younger than two years of age recording demographic, clinical and microbiological data. A total of 657 children with a clinical diagnosis of bronchiolitis were enrolled; 56% children were admitted and 5.9% required PICU admission. The first cases were detected during the summer, peaking in November 2021 and declining into December 2021 with only a few cases detected in January 2022. RSV was the commonest etiological agent, while SARS-CoV-2 was rarely detected and only since the end of December 2021. Disease severity was similar in children with RSV vs. non-RSV bronchiolitis, and in those with a single infectious agent detected compared with children with co-infections. The 2021–2022 bronchiolitis season in Italy started and peaked earlier than the usual pre-pandemic seasons, but had a shorter duration. Importantly, the current bronchiolitis season was not more severe when data were compared with Italian published data, and SARS-CoV-2 was rarely a cause of bronchiolitis in children younger than 24 months of age.
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spelling pubmed-90244622022-04-23 Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study Camporesi, Anna Morello, Rosa Ferro, Valentina Pierantoni, Luca Rocca, Alessandro Lanari, Marcello Trobia, Gian Luca Sciacca, Tiziana Bellinvia, Agata Giuseppina De Ferrari, Alessandra Valentini, Piero Roland, Damian Buonsenso, Danilo Children (Basel) Article The aim of this study was to understand the epidemiology, disease severity, and microbiology of bronchiolitis in Italy during the 2021–2022 cold season, outside of lockdowns. Before COVID-19, the usual bronchiolitis season in Italy would begin in November and end in April, peaking in February. We performed a prospective observational study in four referral pediatric centers located in different geographical areas in Italy (two in the north, one in the center and one in the south). From 1 July 2021 to 31 January 2022, we collected all new clinical diagnoses of bronchiolitis in children younger than two years of age recording demographic, clinical and microbiological data. A total of 657 children with a clinical diagnosis of bronchiolitis were enrolled; 56% children were admitted and 5.9% required PICU admission. The first cases were detected during the summer, peaking in November 2021 and declining into December 2021 with only a few cases detected in January 2022. RSV was the commonest etiological agent, while SARS-CoV-2 was rarely detected and only since the end of December 2021. Disease severity was similar in children with RSV vs. non-RSV bronchiolitis, and in those with a single infectious agent detected compared with children with co-infections. The 2021–2022 bronchiolitis season in Italy started and peaked earlier than the usual pre-pandemic seasons, but had a shorter duration. Importantly, the current bronchiolitis season was not more severe when data were compared with Italian published data, and SARS-CoV-2 was rarely a cause of bronchiolitis in children younger than 24 months of age. MDPI 2022-04-01 /pmc/articles/PMC9024462/ /pubmed/35455535 http://dx.doi.org/10.3390/children9040491 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Camporesi, Anna
Morello, Rosa
Ferro, Valentina
Pierantoni, Luca
Rocca, Alessandro
Lanari, Marcello
Trobia, Gian Luca
Sciacca, Tiziana
Bellinvia, Agata Giuseppina
De Ferrari, Alessandra
Valentini, Piero
Roland, Damian
Buonsenso, Danilo
Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study
title Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study
title_full Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study
title_fullStr Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study
title_full_unstemmed Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study
title_short Epidemiology, Microbiology and Severity of Bronchiolitis in the First Post-Lockdown Cold Season in Three Different Geographical Areas in Italy: A Prospective, Observational Study
title_sort epidemiology, microbiology and severity of bronchiolitis in the first post-lockdown cold season in three different geographical areas in italy: a prospective, observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024462/
https://www.ncbi.nlm.nih.gov/pubmed/35455535
http://dx.doi.org/10.3390/children9040491
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