Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a haematological neoplasm resulting from the accumulation of genetic and epigenetic alterations. Patients’ prognoses vary with AML genetic heterogeneity, which hampers successful treatments. Single-cell approaches have provided new insights of the clonal architecture...

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Autores principales: Redavid, Immacolata, Conserva, Maria Rosa, Anelli, Luisa, Zagaria, Antonella, Specchia, Giorgina, Musto, Pellegrino, Albano, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024495/
https://www.ncbi.nlm.nih.gov/pubmed/35454044
http://dx.doi.org/10.3390/diagnostics12040996
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author Redavid, Immacolata
Conserva, Maria Rosa
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Musto, Pellegrino
Albano, Francesco
author_facet Redavid, Immacolata
Conserva, Maria Rosa
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Musto, Pellegrino
Albano, Francesco
author_sort Redavid, Immacolata
collection PubMed
description Acute myeloid leukemia (AML) is a haematological neoplasm resulting from the accumulation of genetic and epigenetic alterations. Patients’ prognoses vary with AML genetic heterogeneity, which hampers successful treatments. Single-cell approaches have provided new insights of the clonal architecture of AML, revealing the mutational history from diagnosis, during treatment and to relapse. In this review, we imagine single-cell technologies as the Ariadne’s thread that will guide us out of the AML maze, provide a precise identikit of the leukemic cell at single-cell resolution and explore genomic, transcriptomic, epigenetic and proteomic levels.
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spelling pubmed-90244952022-04-23 Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia Redavid, Immacolata Conserva, Maria Rosa Anelli, Luisa Zagaria, Antonella Specchia, Giorgina Musto, Pellegrino Albano, Francesco Diagnostics (Basel) Review Acute myeloid leukemia (AML) is a haematological neoplasm resulting from the accumulation of genetic and epigenetic alterations. Patients’ prognoses vary with AML genetic heterogeneity, which hampers successful treatments. Single-cell approaches have provided new insights of the clonal architecture of AML, revealing the mutational history from diagnosis, during treatment and to relapse. In this review, we imagine single-cell technologies as the Ariadne’s thread that will guide us out of the AML maze, provide a precise identikit of the leukemic cell at single-cell resolution and explore genomic, transcriptomic, epigenetic and proteomic levels. MDPI 2022-04-15 /pmc/articles/PMC9024495/ /pubmed/35454044 http://dx.doi.org/10.3390/diagnostics12040996 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Redavid, Immacolata
Conserva, Maria Rosa
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Musto, Pellegrino
Albano, Francesco
Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia
title Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia
title_full Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia
title_fullStr Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia
title_full_unstemmed Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia
title_short Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia
title_sort single-cell sequencing: ariadne’s thread in the maze of acute myeloid leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024495/
https://www.ncbi.nlm.nih.gov/pubmed/35454044
http://dx.doi.org/10.3390/diagnostics12040996
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