Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity

Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversifi...

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Detalles Bibliográficos
Autores principales: Matz, Alyssa, Qu, Lili, Karlinsey, Keaton, Zhou, Beiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024513/
https://www.ncbi.nlm.nih.gov/pubmed/35456015
http://dx.doi.org/10.3390/cells11081336
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author Matz, Alyssa
Qu, Lili
Karlinsey, Keaton
Zhou, Beiyan
author_facet Matz, Alyssa
Qu, Lili
Karlinsey, Keaton
Zhou, Beiyan
author_sort Matz, Alyssa
collection PubMed
description Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs’ importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress.
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spelling pubmed-90245132022-04-23 Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity Matz, Alyssa Qu, Lili Karlinsey, Keaton Zhou, Beiyan Cells Review Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs’ importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress. MDPI 2022-04-14 /pmc/articles/PMC9024513/ /pubmed/35456015 http://dx.doi.org/10.3390/cells11081336 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matz, Alyssa
Qu, Lili
Karlinsey, Keaton
Zhou, Beiyan
Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
title Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
title_full Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
title_fullStr Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
title_full_unstemmed Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
title_short Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
title_sort impact of microrna regulated macrophage actions on adipose tissue function in obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024513/
https://www.ncbi.nlm.nih.gov/pubmed/35456015
http://dx.doi.org/10.3390/cells11081336
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