Assessing the Impact of Insecticide Resistance on Vector Competence: A Review

SIMPLE SUMMARY: Insects transmit a wide variety of pathogens, including parasites, bacteria, and viruses, to human and economically important crops. Since pathogen transmission threatens public health and economic activities, insecticides are the main strategy to control insect populations. The continued use of insecticides has led to resistant populations where chemicals are no longer effective. It is unknown if insecticide resistance (IR) could impact insects’ other characteristics, such as their ability to infect, maintain infection, or transmit pathogens, a trait known as vector competence (VC). In this review, we analyze the literature that involves the study of VC and IR or insecticide exposure in three main approaches; studies conducted in the field versus laboratory-designed experiments, the impact of insecticide exposure on pathogen transmission, and studies performed on vectors of crop pathogens. The evidence points out three different patterns where enhancement, impairment, or neutral effects are seen between IR and VC. It is of great concern that IR could enhance VC since it increases the risk of epidemics. More detailed and standardized studies are needed to confirm this relationship. Finally, results from this investigation could help create evidence-based vector control programs. ABSTRACT: The primary strategy to avoid adverse impacts from insect-mediated pathogen transmission is the chemical control of vector populations through insecticides; its continued use has led to insecticide resistance and unknown consequences on vector competence. This review aims to systematically analyze and synthesize the research on the influence of insecticide resistance (IR) on vector competence (VC). Thirty studies met the inclusion criteria. Twenty studies, conducted either in laboratory or field settings, described the influence of phenotypic insecticide resistance and mechanisms on VC in vectors of human pathogens. Seven studies showed the effect of exposure to insecticides on VC in vectors of human pathogens. Three studies reported the influence of phenotypic resistance and mechanisms on VC in crop pests. The evidence shows that IR could enhance, impair, or have no direct effect on VC in either field or laboratory-designed studies. Similar positive and negative trends are found in pest vectors in crops and studies of insecticide exposure and VC. Even though there is evidence that exposure to insecticides and IR can enhance VC, thus increasing the risk of pathogen transmission, more investigations are needed to confirm the observed patterns and what implications these factors could have in vector control programs.