Inhibition of the NOTCH1 Pathway in the Stressed Heart Limits Fibrosis and Promotes Recruitment of Non-Myocyte Cells into the Cardiomyocyte Fate

Cardiac pathologies lead to an acute or gradual loss of cardiomyocytes. Because of the limited regenerative capacity of the mammalian heart, cardiomyocytes are only replaced by fibrotic tissue. Excessive fibrosis contributes to the deterioration of cardiac function and the transition to heart failur...

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Detalles Bibliográficos
Autores principales: Nemir, Mohamed, Kay, Maryam, Maison, Damien, Berthonneche, Corinne, Sarre, Alexandre, Plaisance, Isabelle, Pedrazzini, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024539/
https://www.ncbi.nlm.nih.gov/pubmed/35448087
http://dx.doi.org/10.3390/jcdd9040111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024539/
https://www.ncbi.nlm.nih.gov/pubmed/35448087
http://dx.doi.org/10.3390/jcdd9040111

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