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Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era
Sarcopenia has recently been studied in both adults and children and was found to be a prognostic marker for adverse outcome in a variety of patient groups. Our research showed that sarcopenia is a relevant marker in predicting outcome in children with solid organ tumors, such as hepatoblastoma and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024674/ https://www.ncbi.nlm.nih.gov/pubmed/35455957 http://dx.doi.org/10.3390/cells11081278 |
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author | Ritz, Annika Lurz, Eberhard Berger, Michael |
author_facet | Ritz, Annika Lurz, Eberhard Berger, Michael |
author_sort | Ritz, Annika |
collection | PubMed |
description | Sarcopenia has recently been studied in both adults and children and was found to be a prognostic marker for adverse outcome in a variety of patient groups. Our research showed that sarcopenia is a relevant marker in predicting outcome in children with solid organ tumors, such as hepatoblastoma and neuroblastoma. This was especially true in very ill, high-risk groups. Children with cancer have a higher likelihood of ongoing loss of skeletal muscle mass due to a mismatch in energy intake and expenditure. Additionally, the effects of cancer therapy, hormonal alterations, chronic inflammation, multi-organ dysfunction, and a hypermetabolic state all contribute to a loss of skeletal muscle mass. Sarcopenia seems to be able to pinpoint this waste to a high degree in a new and objective way, making it an additional tool in predicting and improving outcome in children. This article focuses on the current state of sarcopenia in children with solid organ tumors. It details the pathophysiological mechanisms behind sarcopenia, highlighting the technical features of the available methods for measuring muscle mass, strength, and function, including artificial intelligence (AI)-based techniques. It also reviews the latest research on sarcopenia in children, focusing on children with solid organ tumors. |
format | Online Article Text |
id | pubmed-9024674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90246742022-04-23 Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era Ritz, Annika Lurz, Eberhard Berger, Michael Cells Review Sarcopenia has recently been studied in both adults and children and was found to be a prognostic marker for adverse outcome in a variety of patient groups. Our research showed that sarcopenia is a relevant marker in predicting outcome in children with solid organ tumors, such as hepatoblastoma and neuroblastoma. This was especially true in very ill, high-risk groups. Children with cancer have a higher likelihood of ongoing loss of skeletal muscle mass due to a mismatch in energy intake and expenditure. Additionally, the effects of cancer therapy, hormonal alterations, chronic inflammation, multi-organ dysfunction, and a hypermetabolic state all contribute to a loss of skeletal muscle mass. Sarcopenia seems to be able to pinpoint this waste to a high degree in a new and objective way, making it an additional tool in predicting and improving outcome in children. This article focuses on the current state of sarcopenia in children with solid organ tumors. It details the pathophysiological mechanisms behind sarcopenia, highlighting the technical features of the available methods for measuring muscle mass, strength, and function, including artificial intelligence (AI)-based techniques. It also reviews the latest research on sarcopenia in children, focusing on children with solid organ tumors. MDPI 2022-04-09 /pmc/articles/PMC9024674/ /pubmed/35455957 http://dx.doi.org/10.3390/cells11081278 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ritz, Annika Lurz, Eberhard Berger, Michael Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era |
title | Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era |
title_full | Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era |
title_fullStr | Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era |
title_full_unstemmed | Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era |
title_short | Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era |
title_sort | sarcopenia in children with solid organ tumors: an instrumental era |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024674/ https://www.ncbi.nlm.nih.gov/pubmed/35455957 http://dx.doi.org/10.3390/cells11081278 |
work_keys_str_mv | AT ritzannika sarcopeniainchildrenwithsolidorgantumorsaninstrumentalera AT lurzeberhard sarcopeniainchildrenwithsolidorgantumorsaninstrumentalera AT bergermichael sarcopeniainchildrenwithsolidorgantumorsaninstrumentalera |