Induction of Heme Oxygenase-1 by 15d-Prostaglandin J(2) Mediated via a ROS-Dependent Sp1 and AP-1 Cascade Suppresses Lipopolysaccharide-Triggered Interleukin-6 Expression in Mouse Brain Microvascular Endothelial Cells

Heme oxygenase-1 (HO-1) has been shown to exert antioxidant, anti-inflammatory, and anti-apoptotic effects in various types of cells. Therefore, the induction of HO-1 is an excellent rationale for the development of protective drugs. 15-Deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) can modulate the...

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Detalles Bibliográficos
Autores principales: Yang, Chien-Chung, Hsiao, Li-Der, Shih, Ya-Fang, Chang, Ching-I, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024691/
https://www.ncbi.nlm.nih.gov/pubmed/35453404
http://dx.doi.org/10.3390/antiox11040719

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