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Development of CAR T Cell Therapy in Children—A Comprehensive Overview

CAR T cell therapy has revolutionized immunotherapy in the last decade with the successful establishment of chimeric antigen receptor (CAR)-expressing cellular therapies as an alternative treatment in relapsed and refractory CD19-positive leukemias and lymphomas. There are fundamental reasons why CA...

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Autores principales: Boettcher, Michael, Joechner, Alexander, Li, Ziduo, Yang, Sile Fiona, Schlegel, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024694/
https://www.ncbi.nlm.nih.gov/pubmed/35456250
http://dx.doi.org/10.3390/jcm11082158
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author Boettcher, Michael
Joechner, Alexander
Li, Ziduo
Yang, Sile Fiona
Schlegel, Patrick
author_facet Boettcher, Michael
Joechner, Alexander
Li, Ziduo
Yang, Sile Fiona
Schlegel, Patrick
author_sort Boettcher, Michael
collection PubMed
description CAR T cell therapy has revolutionized immunotherapy in the last decade with the successful establishment of chimeric antigen receptor (CAR)-expressing cellular therapies as an alternative treatment in relapsed and refractory CD19-positive leukemias and lymphomas. There are fundamental reasons why CAR T cell therapy has been approved by the Food and Drug administration and the European Medicines Agency for pediatric and young adult patients first. Commonly, novel therapies are developed for adult patients and then adapted for pediatric use, due to regulatory and commercial reasons. Both strategic and biological factors have supported the success of CAR T cell therapy in children. Since there is an urgent need for more potent and specific therapies in childhood malignancies, efforts should also include the development of CAR therapeutics and expand applicability by introducing new technologies. Basic aspects, the evolution and the drawbacks of childhood CAR T cell therapy are discussed as along with the latest clinically relevant information.
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spelling pubmed-90246942022-04-23 Development of CAR T Cell Therapy in Children—A Comprehensive Overview Boettcher, Michael Joechner, Alexander Li, Ziduo Yang, Sile Fiona Schlegel, Patrick J Clin Med Review CAR T cell therapy has revolutionized immunotherapy in the last decade with the successful establishment of chimeric antigen receptor (CAR)-expressing cellular therapies as an alternative treatment in relapsed and refractory CD19-positive leukemias and lymphomas. There are fundamental reasons why CAR T cell therapy has been approved by the Food and Drug administration and the European Medicines Agency for pediatric and young adult patients first. Commonly, novel therapies are developed for adult patients and then adapted for pediatric use, due to regulatory and commercial reasons. Both strategic and biological factors have supported the success of CAR T cell therapy in children. Since there is an urgent need for more potent and specific therapies in childhood malignancies, efforts should also include the development of CAR therapeutics and expand applicability by introducing new technologies. Basic aspects, the evolution and the drawbacks of childhood CAR T cell therapy are discussed as along with the latest clinically relevant information. MDPI 2022-04-12 /pmc/articles/PMC9024694/ /pubmed/35456250 http://dx.doi.org/10.3390/jcm11082158 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boettcher, Michael
Joechner, Alexander
Li, Ziduo
Yang, Sile Fiona
Schlegel, Patrick
Development of CAR T Cell Therapy in Children—A Comprehensive Overview
title Development of CAR T Cell Therapy in Children—A Comprehensive Overview
title_full Development of CAR T Cell Therapy in Children—A Comprehensive Overview
title_fullStr Development of CAR T Cell Therapy in Children—A Comprehensive Overview
title_full_unstemmed Development of CAR T Cell Therapy in Children—A Comprehensive Overview
title_short Development of CAR T Cell Therapy in Children—A Comprehensive Overview
title_sort development of car t cell therapy in children—a comprehensive overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024694/
https://www.ncbi.nlm.nih.gov/pubmed/35456250
http://dx.doi.org/10.3390/jcm11082158
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