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Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM(+) and CD90(+) Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

SIMPLE SUMMARY: Cancer stem cells are a distinct tumor subpopulation associated with poor outcome. The epithelial cell adhesion molecule (EpCAM) and Thy-1 cell surface antigen (CD90) have been implicated as cancer stem cell (CSC) markers in hepatocellular carcinoma (HCC). Eradication of those CSCs i...

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Detalles Bibliográficos
Autores principales:	Moustafa, Mohamed, Dähling, Katarzyna-Krystyna, Günther, Armin, Riebandt, Leonie, Smit, Daniel J., Riecken, Kristoffer, Schröder, Carina, Zhuang, Ruimeng, Krech, Till, Kriegs, Malte, Fehse, Boris, Izbicki, Jakob R., Fischer, Lutz, Nashan, Björn, Li, Jun, Jücker, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024696/ https://www.ncbi.nlm.nih.gov/pubmed/35454789 http://dx.doi.org/10.3390/cancers14081882

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