Cargando…
Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome
Our aim was to investigate the distribution of acid-base disorders in patients with COVID-19 ARDS using both the Henderson–Hasselbalch and Stewart’s approach and to explore if hypoxemia can influence acid-base disorders. COVID-19 ARDS patients, within the first 48 h of the need for a non-invasive re...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024702/ https://www.ncbi.nlm.nih.gov/pubmed/35456186 http://dx.doi.org/10.3390/jcm11082093 |
_version_ | 1784690669898432512 |
---|---|
author | Chiumello, Davide Pozzi, Tommaso Fratti, Isabella Modafferi, Leo Montante, Marialaura Papa, Giuseppe Francesco Sferrazza Coppola, Silvia |
author_facet | Chiumello, Davide Pozzi, Tommaso Fratti, Isabella Modafferi, Leo Montante, Marialaura Papa, Giuseppe Francesco Sferrazza Coppola, Silvia |
author_sort | Chiumello, Davide |
collection | PubMed |
description | Our aim was to investigate the distribution of acid-base disorders in patients with COVID-19 ARDS using both the Henderson–Hasselbalch and Stewart’s approach and to explore if hypoxemia can influence acid-base disorders. COVID-19 ARDS patients, within the first 48 h of the need for a non-invasive respiratory support, were retrospectively enrolled. Respiratory support was provided by helmet continuous positive airway pressure (CPAP) or by non-invasive ventilation. One hundred and four patients were enrolled, 84% treated with CPAP and 16% with non-invasive ventilation. Using the Henderson–Hasselbalch approach, 40% and 32% of patients presented respiratory and metabolic alkalosis, respectively; 13% did not present acid-base disorders. Using Stewart’s approach, 43% and 33% had a respiratory and metabolic alkalosis, respectively; 12% of patients had a mixed disorder characterized by normal pH with a lower SID. The severe hypoxemic and moderate hypoxemic group presented similar frequencies of respiratory and metabolic alkalosis. The most frequent acid-base disorders were respiratory and metabolic alkalosis using both the Henderson–Hasselbalch and Stewart’s approach. Stewart’s approach detected mixed disorders with a normal pH probably generated by the combined effect of strong ions and weak acids. The impairment of oxygenation did not affect acid-base disorders. |
format | Online Article Text |
id | pubmed-9024702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90247022022-04-23 Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome Chiumello, Davide Pozzi, Tommaso Fratti, Isabella Modafferi, Leo Montante, Marialaura Papa, Giuseppe Francesco Sferrazza Coppola, Silvia J Clin Med Article Our aim was to investigate the distribution of acid-base disorders in patients with COVID-19 ARDS using both the Henderson–Hasselbalch and Stewart’s approach and to explore if hypoxemia can influence acid-base disorders. COVID-19 ARDS patients, within the first 48 h of the need for a non-invasive respiratory support, were retrospectively enrolled. Respiratory support was provided by helmet continuous positive airway pressure (CPAP) or by non-invasive ventilation. One hundred and four patients were enrolled, 84% treated with CPAP and 16% with non-invasive ventilation. Using the Henderson–Hasselbalch approach, 40% and 32% of patients presented respiratory and metabolic alkalosis, respectively; 13% did not present acid-base disorders. Using Stewart’s approach, 43% and 33% had a respiratory and metabolic alkalosis, respectively; 12% of patients had a mixed disorder characterized by normal pH with a lower SID. The severe hypoxemic and moderate hypoxemic group presented similar frequencies of respiratory and metabolic alkalosis. The most frequent acid-base disorders were respiratory and metabolic alkalosis using both the Henderson–Hasselbalch and Stewart’s approach. Stewart’s approach detected mixed disorders with a normal pH probably generated by the combined effect of strong ions and weak acids. The impairment of oxygenation did not affect acid-base disorders. MDPI 2022-04-08 /pmc/articles/PMC9024702/ /pubmed/35456186 http://dx.doi.org/10.3390/jcm11082093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chiumello, Davide Pozzi, Tommaso Fratti, Isabella Modafferi, Leo Montante, Marialaura Papa, Giuseppe Francesco Sferrazza Coppola, Silvia Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome |
title | Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome |
title_full | Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome |
title_fullStr | Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome |
title_full_unstemmed | Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome |
title_short | Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome |
title_sort | acid-base disorders in covid-19 patients with acute respiratory distress syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024702/ https://www.ncbi.nlm.nih.gov/pubmed/35456186 http://dx.doi.org/10.3390/jcm11082093 |
work_keys_str_mv | AT chiumellodavide acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome AT pozzitommaso acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome AT frattiisabella acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome AT modafferileo acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome AT montantemarialaura acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome AT papagiuseppefrancescosferrazza acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome AT coppolasilvia acidbasedisordersincovid19patientswithacuterespiratorydistresssyndrome |