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Perspectives on Ovarian Cancer 1809 to 2022 and Beyond

Unlike many other malignancies, overall survival for women with epithelial ovarian cancer has improved only modestly over the last half-century. The perspectives presented here detail the views of a gynecologic oncologist looking back and the view of the academic editor looking forward. Surgical beg...

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Autores principales: Lawton, Frank G., Pavlik, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024743/
https://www.ncbi.nlm.nih.gov/pubmed/35453839
http://dx.doi.org/10.3390/diagnostics12040791
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author Lawton, Frank G.
Pavlik, Edward J.
author_facet Lawton, Frank G.
Pavlik, Edward J.
author_sort Lawton, Frank G.
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description Unlike many other malignancies, overall survival for women with epithelial ovarian cancer has improved only modestly over the last half-century. The perspectives presented here detail the views of a gynecologic oncologist looking back and the view of the academic editor looking forward. Surgical beginnings in 1809 are merged with genomics, surgical advances, and precision therapy at present and for the future. Presentations in this special issue focus on factors related to the diagnosis of ovarian cancer: (1) markers for the preoperative assessment of primary and metastatic ovarian tumors, (2) demonstrations of the presence of pelvic fluid in ultrasound studies of ovarian malignancies, (3) the effects of age, menopausal status, and body habitus on ovarian visualization, (4) the ability of OVA1 to detect ovarian cancers when Ca125 was not informative, (5) the detection of tumor-specific changes in cell adhesion molecules by tissue-based staining, (6) presentation of a high discrimination model for ovarian cancer using IOTA Simple Rules and CA125, (7) review of low-grade serous carcinoma of the ovary, and (8) a comprehensive case report on ovarian carcinosarcoma.
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spelling pubmed-90247432022-04-23 Perspectives on Ovarian Cancer 1809 to 2022 and Beyond Lawton, Frank G. Pavlik, Edward J. Diagnostics (Basel) Perspective Unlike many other malignancies, overall survival for women with epithelial ovarian cancer has improved only modestly over the last half-century. The perspectives presented here detail the views of a gynecologic oncologist looking back and the view of the academic editor looking forward. Surgical beginnings in 1809 are merged with genomics, surgical advances, and precision therapy at present and for the future. Presentations in this special issue focus on factors related to the diagnosis of ovarian cancer: (1) markers for the preoperative assessment of primary and metastatic ovarian tumors, (2) demonstrations of the presence of pelvic fluid in ultrasound studies of ovarian malignancies, (3) the effects of age, menopausal status, and body habitus on ovarian visualization, (4) the ability of OVA1 to detect ovarian cancers when Ca125 was not informative, (5) the detection of tumor-specific changes in cell adhesion molecules by tissue-based staining, (6) presentation of a high discrimination model for ovarian cancer using IOTA Simple Rules and CA125, (7) review of low-grade serous carcinoma of the ovary, and (8) a comprehensive case report on ovarian carcinosarcoma. MDPI 2022-03-24 /pmc/articles/PMC9024743/ /pubmed/35453839 http://dx.doi.org/10.3390/diagnostics12040791 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Lawton, Frank G.
Pavlik, Edward J.
Perspectives on Ovarian Cancer 1809 to 2022 and Beyond
title Perspectives on Ovarian Cancer 1809 to 2022 and Beyond
title_full Perspectives on Ovarian Cancer 1809 to 2022 and Beyond
title_fullStr Perspectives on Ovarian Cancer 1809 to 2022 and Beyond
title_full_unstemmed Perspectives on Ovarian Cancer 1809 to 2022 and Beyond
title_short Perspectives on Ovarian Cancer 1809 to 2022 and Beyond
title_sort perspectives on ovarian cancer 1809 to 2022 and beyond
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024743/
https://www.ncbi.nlm.nih.gov/pubmed/35453839
http://dx.doi.org/10.3390/diagnostics12040791
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