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TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells

A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorganization of th...

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Detalles Bibliográficos
Autores principales:	Stieglitz, Florian, Gerhard, Ralf, Hönig, Rabea, Giehl, Klaudia, Pich, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024770/ https://www.ncbi.nlm.nih.gov/pubmed/35457076 http://dx.doi.org/10.3390/ijms23084258

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