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An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses
The chicken astrovirus (CAstV) is a ubiquitous enteric RNA virus that has been associated mainly with conditions, such as the runting-stunting syndrome, severe kidney disease, visceral gout, and white chick syndrome, in broiler-type chickens worldwide. Sequence analysis of the capsid genes’ amino ac...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024793/ https://www.ncbi.nlm.nih.gov/pubmed/35458451 http://dx.doi.org/10.3390/v14040722 |
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author | Raji, Abdullahi Abdullahi Omar, Abdul Rahman |
author_facet | Raji, Abdullahi Abdullahi Omar, Abdul Rahman |
author_sort | Raji, Abdullahi Abdullahi |
collection | PubMed |
description | The chicken astrovirus (CAstV) is a ubiquitous enteric RNA virus that has been associated mainly with conditions, such as the runting-stunting syndrome, severe kidney disease, visceral gout, and white chick syndrome, in broiler-type chickens worldwide. Sequence analysis of the capsid genes’ amino acids of the strains involved in these conditions reveals a genetic relationship and diversity between and within the CAstV genogroups and subgroups based on phylogenetic analysis, genetic distance (p-dist), and pathogenicity. While the two genogroups (A and B) are demarcated phylogenetically, their pairwise amino acid sequence identity is 39% to 42% at a p-dist of 0.59 to 0.62. Group-A consists of three subgroups (Ai, Aii, and Aiii) with an inter- and intra-subgroup amino acid identity of 78% to 82% and 92% to 100%, respectively, and a p-dist of 0.18 to 0.22. On the other hand, the six subgroups (Bi, Bii, Biii, Biv, Bv, and Bvi) in Group-B, with a p-dist of 0.07 to 0.18, have an inter- and intra-subgroup amino acid identity of 82% to 93% and 93% to 100%, respectively. However, these groupings have little to no effect on determining the type of CAstV-associated pathology in chickens. |
format | Online Article Text |
id | pubmed-9024793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90247932022-04-23 An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses Raji, Abdullahi Abdullahi Omar, Abdul Rahman Viruses Review The chicken astrovirus (CAstV) is a ubiquitous enteric RNA virus that has been associated mainly with conditions, such as the runting-stunting syndrome, severe kidney disease, visceral gout, and white chick syndrome, in broiler-type chickens worldwide. Sequence analysis of the capsid genes’ amino acids of the strains involved in these conditions reveals a genetic relationship and diversity between and within the CAstV genogroups and subgroups based on phylogenetic analysis, genetic distance (p-dist), and pathogenicity. While the two genogroups (A and B) are demarcated phylogenetically, their pairwise amino acid sequence identity is 39% to 42% at a p-dist of 0.59 to 0.62. Group-A consists of three subgroups (Ai, Aii, and Aiii) with an inter- and intra-subgroup amino acid identity of 78% to 82% and 92% to 100%, respectively, and a p-dist of 0.18 to 0.22. On the other hand, the six subgroups (Bi, Bii, Biii, Biv, Bv, and Bvi) in Group-B, with a p-dist of 0.07 to 0.18, have an inter- and intra-subgroup amino acid identity of 82% to 93% and 93% to 100%, respectively. However, these groupings have little to no effect on determining the type of CAstV-associated pathology in chickens. MDPI 2022-03-30 /pmc/articles/PMC9024793/ /pubmed/35458451 http://dx.doi.org/10.3390/v14040722 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Raji, Abdullahi Abdullahi Omar, Abdul Rahman An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses |
title | An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses |
title_full | An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses |
title_fullStr | An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses |
title_full_unstemmed | An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses |
title_short | An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses |
title_sort | insight into the molecular characteristics and associated pathology of chicken astroviruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024793/ https://www.ncbi.nlm.nih.gov/pubmed/35458451 http://dx.doi.org/10.3390/v14040722 |
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