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Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors

Cardiovascular diseases (CVDs) represent the leading cause of death worldwide, being responsible for about one third of deaths. Among CVDs, coronary artery diseases (CADs) are characterized by vascular endothelium dysfunction due to oxidative and inflammatory damages, the oxidation of circulating lo...

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Autores principales: Leone, Kevin, Micheletto, Marta, Di Maira, Giovanni, Tedesco, Erik, Benetti, Federico, Zaloker, Urška
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024870/
https://www.ncbi.nlm.nih.gov/pubmed/35453303
http://dx.doi.org/10.3390/antiox11040618
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author Leone, Kevin
Micheletto, Marta
Di Maira, Giovanni
Tedesco, Erik
Benetti, Federico
Zaloker, Urška
author_facet Leone, Kevin
Micheletto, Marta
Di Maira, Giovanni
Tedesco, Erik
Benetti, Federico
Zaloker, Urška
author_sort Leone, Kevin
collection PubMed
description Cardiovascular diseases (CVDs) represent the leading cause of death worldwide, being responsible for about one third of deaths. Among CVDs, coronary artery diseases (CADs) are characterized by vascular endothelium dysfunction due to oxidative and inflammatory damages, the oxidation of circulating low-density lipoproteins (LDL) and high-density lipoproteins (HDL), and the production of ROS in the steatotic liver with the consequent increase of lipids and cholesterol. Together with CADs, heart failure (HF) represents another high-mortality rate CVD. A major risk factor for HF is hypertension that is accompanied by oxidative stress. Phytoextracts, rich in antioxidant and anti-inflammatory compounds, may have therapeutic value as they can interfere with several CVDs risk factors. In this work, a novel silver fir (Abies alba) bark extract, Abigenol(®)/AlbiPhenol(®), was studied. First, Abigenol(®)/AlbiPhenol(®) cytotoxicity, bioaccessibility and bioavailability were evaluated by using an in vitro digestion model. Abigenol(®)/AlbiPhenol(®) was shown to be non-cytotoxic and showed good bioaccessibility. Then, by using in vitro hepatic, cardiac and vascular models, its antioxidant and anti-steatotic properties were assessed. Abigenol(®)/AlbiPhenol(®) showed an effective antioxidant action, and it was able to inhibit LDL and HDL oxidation, the main actors in atherosclerotic plaque formation. In steatotic conditions, Abigenol(®)/AlbiPhenol(®) induces decreased lipid and cholesterol accumulation in hepatocytes. In addition, in a cardiac model, the formulation reduced the activity of the hypertension-related angiotensin-converting enzyme (ACE). Altogether, these findings reveal a potential application of Abigenol(®)/AlbiPhenol(®) in the prevention and treatment of CVDs.
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spelling pubmed-90248702022-04-23 Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors Leone, Kevin Micheletto, Marta Di Maira, Giovanni Tedesco, Erik Benetti, Federico Zaloker, Urška Antioxidants (Basel) Article Cardiovascular diseases (CVDs) represent the leading cause of death worldwide, being responsible for about one third of deaths. Among CVDs, coronary artery diseases (CADs) are characterized by vascular endothelium dysfunction due to oxidative and inflammatory damages, the oxidation of circulating low-density lipoproteins (LDL) and high-density lipoproteins (HDL), and the production of ROS in the steatotic liver with the consequent increase of lipids and cholesterol. Together with CADs, heart failure (HF) represents another high-mortality rate CVD. A major risk factor for HF is hypertension that is accompanied by oxidative stress. Phytoextracts, rich in antioxidant and anti-inflammatory compounds, may have therapeutic value as they can interfere with several CVDs risk factors. In this work, a novel silver fir (Abies alba) bark extract, Abigenol(®)/AlbiPhenol(®), was studied. First, Abigenol(®)/AlbiPhenol(®) cytotoxicity, bioaccessibility and bioavailability were evaluated by using an in vitro digestion model. Abigenol(®)/AlbiPhenol(®) was shown to be non-cytotoxic and showed good bioaccessibility. Then, by using in vitro hepatic, cardiac and vascular models, its antioxidant and anti-steatotic properties were assessed. Abigenol(®)/AlbiPhenol(®) showed an effective antioxidant action, and it was able to inhibit LDL and HDL oxidation, the main actors in atherosclerotic plaque formation. In steatotic conditions, Abigenol(®)/AlbiPhenol(®) induces decreased lipid and cholesterol accumulation in hepatocytes. In addition, in a cardiac model, the formulation reduced the activity of the hypertension-related angiotensin-converting enzyme (ACE). Altogether, these findings reveal a potential application of Abigenol(®)/AlbiPhenol(®) in the prevention and treatment of CVDs. MDPI 2022-03-23 /pmc/articles/PMC9024870/ /pubmed/35453303 http://dx.doi.org/10.3390/antiox11040618 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leone, Kevin
Micheletto, Marta
Di Maira, Giovanni
Tedesco, Erik
Benetti, Federico
Zaloker, Urška
Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors
title Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors
title_full Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors
title_fullStr Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors
title_full_unstemmed Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors
title_short Role of a Novel Silver Fir (Abies alba) Extract, Abigenol(®)/AlbiPhenol(®), in Modulating Cardiovascular Disorders: Key Factors
title_sort role of a novel silver fir (abies alba) extract, abigenol(®)/albiphenol(®), in modulating cardiovascular disorders: key factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024870/
https://www.ncbi.nlm.nih.gov/pubmed/35453303
http://dx.doi.org/10.3390/antiox11040618
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