Meningioma Cell Invasion into DuraGen-Derived Dura Mater: A Case Report

Background: Dura mater infiltration is the main growth pattern of meningiomas. Local recurrence may occur in any type of meningioma, but it is more likely so in atypical meningiomas. Therefore, a wide resection of tumor cell-invaded dura mater is necessary to avoid recurrence. DuraGen(®) (an artificial dural substitute) can be used for dural reconstruction in meningiomas. Here, we report a rare case of a patient with atypical meningioma that invaded into the DuraGen(®)-derived mature dura mater. Case presentation: A 66-year-old female showed a three-time recurrence of atypical meningioma. Simpson grade I resection (en bloc tumor with autologous dura mater and DuraGen(®)-derived dura mater resection) was achieved at the 3rd recurrence. Collagen fibers running regularly and transversely were observed in the DuraGen(®)-derived dura mater resembling the autologous meningeal layer. Meningioma cell invasion, displayed by occasional EMA immunostaining, was observed in the DuraGen(®)-derived dura mater. Conclusions: This case indicates that meningioma cells may invade and survive in the DuraGen(®-)derived dura mater. Whether or not DuraGen(®) is not appropriate as a dural substitute remains unanswered. Further experiences are needed to validate these findings in large sample sizes.