Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study

Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimu...

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Autores principales: Karmelić, Ivana, Salarić, Ivan, Baždarić, Ksenija, Rožman, Marko, Zajc, Ivan, Mravak-Stipetić, Marinka, Bago, Ivona, Brajdić, Davor, Lovrić, Jasna, Macan, Darko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024948/
https://www.ncbi.nlm.nih.gov/pubmed/35448064
http://dx.doi.org/10.3390/dj10040070
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author Karmelić, Ivana
Salarić, Ivan
Baždarić, Ksenija
Rožman, Marko
Zajc, Ivan
Mravak-Stipetić, Marinka
Bago, Ivona
Brajdić, Davor
Lovrić, Jasna
Macan, Darko
author_facet Karmelić, Ivana
Salarić, Ivan
Baždarić, Ksenija
Rožman, Marko
Zajc, Ivan
Mravak-Stipetić, Marinka
Bago, Ivona
Brajdić, Davor
Lovrić, Jasna
Macan, Darko
author_sort Karmelić, Ivana
collection PubMed
description Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age-matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics.
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spelling pubmed-90249482022-04-23 Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study Karmelić, Ivana Salarić, Ivan Baždarić, Ksenija Rožman, Marko Zajc, Ivan Mravak-Stipetić, Marinka Bago, Ivona Brajdić, Davor Lovrić, Jasna Macan, Darko Dent J (Basel) Article Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age-matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics. MDPI 2022-04-15 /pmc/articles/PMC9024948/ /pubmed/35448064 http://dx.doi.org/10.3390/dj10040070 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karmelić, Ivana
Salarić, Ivan
Baždarić, Ksenija
Rožman, Marko
Zajc, Ivan
Mravak-Stipetić, Marinka
Bago, Ivona
Brajdić, Davor
Lovrić, Jasna
Macan, Darko
Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study
title Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study
title_full Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study
title_fullStr Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study
title_full_unstemmed Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study
title_short Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study
title_sort salivary scca1, scca2 and trop2 in oral cancer patients—a cross-sectional pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024948/
https://www.ncbi.nlm.nih.gov/pubmed/35448064
http://dx.doi.org/10.3390/dj10040070
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