Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells

How immune tolerance is lost to pancreatic β-cell peptides triggering autoimmune type 1 diabetes is enigmatic. We have shown that loss of the proinsulin chaperone glucose-regulated protein (GRP) 94 from the endoplasmic reticulum (ER) leads to mishandling of proinsulin, ER stress, and activation of t...

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Detalles Bibliográficos
Autores principales: Khilji, Muhammad Saad, Faridi, Pouya, Pinheiro-Machado, Erika, Hoefner, Carolin, Dahlby, Tina, Aranha, Ritchlynn, Buus, Søren, Nielsen, Morten, Klusek, Justyna, Mandrup-Poulsen, Thomas, Pandey, Kirti, Purcell, Anthony W., Marzec, Michal T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024965/
https://www.ncbi.nlm.nih.gov/pubmed/35453564
http://dx.doi.org/10.3390/biomedicines10040814

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