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The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024980/ https://www.ncbi.nlm.nih.gov/pubmed/35457023 http://dx.doi.org/10.3390/ijms23084205 |
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author | Korbecki, Jan Gąssowska-Dobrowolska, Magdalena Wójcik, Jerzy Szatkowska, Iwona Barczak, Katarzyna Chlubek, Mikołaj Baranowska-Bosiacka, Irena |
author_facet | Korbecki, Jan Gąssowska-Dobrowolska, Magdalena Wójcik, Jerzy Szatkowska, Iwona Barczak, Katarzyna Chlubek, Mikołaj Baranowska-Bosiacka, Irena |
author_sort | Korbecki, Jan |
collection | PubMed |
description | This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscle and the nervous system. For this reason, we describe its effects on hematopoietic stem cells, myoblasts, oligodendrocyte progenitors and osteoclast precursors. We also present the involvement of CXCL1 in diseases of selected tissues and organs including Alzheimer’s disease, epilepsy, herpes simplex virus type 1 (HSV-1) encephalitis, ischemic stroke, major depression, multiple sclerosis, neuromyelitis optica, neuropathic pain, osteoporosis, prion diseases, rheumatoid arthritis, tick-borne encephalitis (TBE), traumatic spinal cord injury and West Nile fever. |
format | Online Article Text |
id | pubmed-9024980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90249802022-04-23 The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System Korbecki, Jan Gąssowska-Dobrowolska, Magdalena Wójcik, Jerzy Szatkowska, Iwona Barczak, Katarzyna Chlubek, Mikołaj Baranowska-Bosiacka, Irena Int J Mol Sci Review This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscle and the nervous system. For this reason, we describe its effects on hematopoietic stem cells, myoblasts, oligodendrocyte progenitors and osteoclast precursors. We also present the involvement of CXCL1 in diseases of selected tissues and organs including Alzheimer’s disease, epilepsy, herpes simplex virus type 1 (HSV-1) encephalitis, ischemic stroke, major depression, multiple sclerosis, neuromyelitis optica, neuropathic pain, osteoporosis, prion diseases, rheumatoid arthritis, tick-borne encephalitis (TBE), traumatic spinal cord injury and West Nile fever. MDPI 2022-04-11 /pmc/articles/PMC9024980/ /pubmed/35457023 http://dx.doi.org/10.3390/ijms23084205 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Korbecki, Jan Gąssowska-Dobrowolska, Magdalena Wójcik, Jerzy Szatkowska, Iwona Barczak, Katarzyna Chlubek, Mikołaj Baranowska-Bosiacka, Irena The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System |
title | The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System |
title_full | The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System |
title_fullStr | The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System |
title_full_unstemmed | The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System |
title_short | The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System |
title_sort | importance of cxcl1 in physiology and noncancerous diseases of bone, bone marrow, muscle and the nervous system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024980/ https://www.ncbi.nlm.nih.gov/pubmed/35457023 http://dx.doi.org/10.3390/ijms23084205 |
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