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The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System

This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscl...

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Autores principales: Korbecki, Jan, Gąssowska-Dobrowolska, Magdalena, Wójcik, Jerzy, Szatkowska, Iwona, Barczak, Katarzyna, Chlubek, Mikołaj, Baranowska-Bosiacka, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024980/
https://www.ncbi.nlm.nih.gov/pubmed/35457023
http://dx.doi.org/10.3390/ijms23084205
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author Korbecki, Jan
Gąssowska-Dobrowolska, Magdalena
Wójcik, Jerzy
Szatkowska, Iwona
Barczak, Katarzyna
Chlubek, Mikołaj
Baranowska-Bosiacka, Irena
author_facet Korbecki, Jan
Gąssowska-Dobrowolska, Magdalena
Wójcik, Jerzy
Szatkowska, Iwona
Barczak, Katarzyna
Chlubek, Mikołaj
Baranowska-Bosiacka, Irena
author_sort Korbecki, Jan
collection PubMed
description This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscle and the nervous system. For this reason, we describe its effects on hematopoietic stem cells, myoblasts, oligodendrocyte progenitors and osteoclast precursors. We also present the involvement of CXCL1 in diseases of selected tissues and organs including Alzheimer’s disease, epilepsy, herpes simplex virus type 1 (HSV-1) encephalitis, ischemic stroke, major depression, multiple sclerosis, neuromyelitis optica, neuropathic pain, osteoporosis, prion diseases, rheumatoid arthritis, tick-borne encephalitis (TBE), traumatic spinal cord injury and West Nile fever.
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spelling pubmed-90249802022-04-23 The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System Korbecki, Jan Gąssowska-Dobrowolska, Magdalena Wójcik, Jerzy Szatkowska, Iwona Barczak, Katarzyna Chlubek, Mikołaj Baranowska-Bosiacka, Irena Int J Mol Sci Review This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscle and the nervous system. For this reason, we describe its effects on hematopoietic stem cells, myoblasts, oligodendrocyte progenitors and osteoclast precursors. We also present the involvement of CXCL1 in diseases of selected tissues and organs including Alzheimer’s disease, epilepsy, herpes simplex virus type 1 (HSV-1) encephalitis, ischemic stroke, major depression, multiple sclerosis, neuromyelitis optica, neuropathic pain, osteoporosis, prion diseases, rheumatoid arthritis, tick-borne encephalitis (TBE), traumatic spinal cord injury and West Nile fever. MDPI 2022-04-11 /pmc/articles/PMC9024980/ /pubmed/35457023 http://dx.doi.org/10.3390/ijms23084205 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Korbecki, Jan
Gąssowska-Dobrowolska, Magdalena
Wójcik, Jerzy
Szatkowska, Iwona
Barczak, Katarzyna
Chlubek, Mikołaj
Baranowska-Bosiacka, Irena
The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
title The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
title_full The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
title_fullStr The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
title_full_unstemmed The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
title_short The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
title_sort importance of cxcl1 in physiology and noncancerous diseases of bone, bone marrow, muscle and the nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024980/
https://www.ncbi.nlm.nih.gov/pubmed/35457023
http://dx.doi.org/10.3390/ijms23084205
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