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Porcine Models of Heart Regeneration

Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting...

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Detalles Bibliográficos
Autores principales: Velayutham, Nivedhitha, Yutzey, Katherine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025077/
https://www.ncbi.nlm.nih.gov/pubmed/35448069
http://dx.doi.org/10.3390/jcdd9040093
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author Velayutham, Nivedhitha
Yutzey, Katherine E.
author_facet Velayutham, Nivedhitha
Yutzey, Katherine E.
author_sort Velayutham, Nivedhitha
collection PubMed
description Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting possibilities for studying cardiac regeneration with the goal of improved clinical translation to humans. However, while swine hearts are anatomically similar to humans, fundamental differences exist in growth mechanisms, nucleation, and the maturation of pig cardiomyocytes, which could present difficulties for the translation of preclinical findings in swine to human therapeutics. In this review, we discuss the maturational dynamics of pig cardiomyocytes and their capacity for proliferative cardiac regeneration during early neonatal development to provide a perspective on swine as a preclinical model for developing cardiac gene- and cell-based regenerative therapeutics.
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spelling pubmed-90250772022-04-23 Porcine Models of Heart Regeneration Velayutham, Nivedhitha Yutzey, Katherine E. J Cardiovasc Dev Dis Review Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting possibilities for studying cardiac regeneration with the goal of improved clinical translation to humans. However, while swine hearts are anatomically similar to humans, fundamental differences exist in growth mechanisms, nucleation, and the maturation of pig cardiomyocytes, which could present difficulties for the translation of preclinical findings in swine to human therapeutics. In this review, we discuss the maturational dynamics of pig cardiomyocytes and their capacity for proliferative cardiac regeneration during early neonatal development to provide a perspective on swine as a preclinical model for developing cardiac gene- and cell-based regenerative therapeutics. MDPI 2022-03-23 /pmc/articles/PMC9025077/ /pubmed/35448069 http://dx.doi.org/10.3390/jcdd9040093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Velayutham, Nivedhitha
Yutzey, Katherine E.
Porcine Models of Heart Regeneration
title Porcine Models of Heart Regeneration
title_full Porcine Models of Heart Regeneration
title_fullStr Porcine Models of Heart Regeneration
title_full_unstemmed Porcine Models of Heart Regeneration
title_short Porcine Models of Heart Regeneration
title_sort porcine models of heart regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025077/
https://www.ncbi.nlm.nih.gov/pubmed/35448069
http://dx.doi.org/10.3390/jcdd9040093
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