Cargando…
Porcine Models of Heart Regeneration
Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025077/ https://www.ncbi.nlm.nih.gov/pubmed/35448069 http://dx.doi.org/10.3390/jcdd9040093 |
_version_ | 1784690777986695168 |
---|---|
author | Velayutham, Nivedhitha Yutzey, Katherine E. |
author_facet | Velayutham, Nivedhitha Yutzey, Katherine E. |
author_sort | Velayutham, Nivedhitha |
collection | PubMed |
description | Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting possibilities for studying cardiac regeneration with the goal of improved clinical translation to humans. However, while swine hearts are anatomically similar to humans, fundamental differences exist in growth mechanisms, nucleation, and the maturation of pig cardiomyocytes, which could present difficulties for the translation of preclinical findings in swine to human therapeutics. In this review, we discuss the maturational dynamics of pig cardiomyocytes and their capacity for proliferative cardiac regeneration during early neonatal development to provide a perspective on swine as a preclinical model for developing cardiac gene- and cell-based regenerative therapeutics. |
format | Online Article Text |
id | pubmed-9025077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90250772022-04-23 Porcine Models of Heart Regeneration Velayutham, Nivedhitha Yutzey, Katherine E. J Cardiovasc Dev Dis Review Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting possibilities for studying cardiac regeneration with the goal of improved clinical translation to humans. However, while swine hearts are anatomically similar to humans, fundamental differences exist in growth mechanisms, nucleation, and the maturation of pig cardiomyocytes, which could present difficulties for the translation of preclinical findings in swine to human therapeutics. In this review, we discuss the maturational dynamics of pig cardiomyocytes and their capacity for proliferative cardiac regeneration during early neonatal development to provide a perspective on swine as a preclinical model for developing cardiac gene- and cell-based regenerative therapeutics. MDPI 2022-03-23 /pmc/articles/PMC9025077/ /pubmed/35448069 http://dx.doi.org/10.3390/jcdd9040093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Velayutham, Nivedhitha Yutzey, Katherine E. Porcine Models of Heart Regeneration |
title | Porcine Models of Heart Regeneration |
title_full | Porcine Models of Heart Regeneration |
title_fullStr | Porcine Models of Heart Regeneration |
title_full_unstemmed | Porcine Models of Heart Regeneration |
title_short | Porcine Models of Heart Regeneration |
title_sort | porcine models of heart regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025077/ https://www.ncbi.nlm.nih.gov/pubmed/35448069 http://dx.doi.org/10.3390/jcdd9040093 |
work_keys_str_mv | AT velayuthamnivedhitha porcinemodelsofheartregeneration AT yutzeykatherinee porcinemodelsofheartregeneration |