Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells

Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-...

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Detalles Bibliográficos
Autores principales: Singh, Simranjit X., Yang, Rui, Roso, Kristen, Hansen, Landon J., Du, Changzheng, Chen, Lee H., Greer, Paula K., Pirozzi, Christopher J., He, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025092/
https://www.ncbi.nlm.nih.gov/pubmed/35453502
http://dx.doi.org/10.3390/biomedicines10040751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025092/
https://www.ncbi.nlm.nih.gov/pubmed/35453502
http://dx.doi.org/10.3390/biomedicines10040751

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