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Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis

Endometriosis or adenomyosis can be clinically diagnosed by ultrasound, symptoms, physical examination, and serum CA125. The urinary markers need to be investigated. The aim of our study was to investigate the urinary markers of clinical endometriosis/adenomyosis, and the correlation of serum CA125...

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Autores principales: Chen, Wei-Chun, Cheng, Chao-Min, Liao, Wan-Ting, Chang, Ting-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025125/
https://www.ncbi.nlm.nih.gov/pubmed/35453583
http://dx.doi.org/10.3390/biomedicines10040833
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author Chen, Wei-Chun
Cheng, Chao-Min
Liao, Wan-Ting
Chang, Ting-Chang
author_facet Chen, Wei-Chun
Cheng, Chao-Min
Liao, Wan-Ting
Chang, Ting-Chang
author_sort Chen, Wei-Chun
collection PubMed
description Endometriosis or adenomyosis can be clinically diagnosed by ultrasound, symptoms, physical examination, and serum CA125. The urinary markers need to be investigated. The aim of our study was to investigate the urinary markers of clinical endometriosis/adenomyosis, and the correlation of serum CA125 was also studied. From the literature, alpha-1 antitrypsin (A1AT), enolase-1, vitamin D binding protein (VDBP), and CA125 in urine and serum were used in our study and measured by enzyme-linked immunosorbent assays (ELISA). Further clinical correlation and detection performance were evaluated. We enrolled 19 normal controls and 33 patients clinically diagnosed with endometriosis/adenomyosis. There were significant differences between studied patients and normal controls, as follows: serum CA125 (130.91 vs. 19.75 U/mL, p = 0.004); urinary CA125-creatinine ratio (5.591 vs. 0.254 ng/mg, p = 0.028); and urinary VDBP-creatinine ratio (28.028 vs. 7.301 ng/mg, p = 0.018). For diagnostic performances, serum CA125 provided the best results, with an area under curve (AUC) of 0.888 (p = 0.001) and accuracy of 86.5%. Other excellent results were also found using urinary VDBP (AUC 0.841, p = 0.001) and A1AT (AUC 0.722, p = 0.011) creatinine ratio. Using three combined biomarkers, serum CA125, urinary VDBP, and A1AT creatinine ratio, provided good detection power (AUC 0.913, p = 0.001, sensitivity 90.9%, specificity 76.5%). Double urine markers used in combination with VDBP and A1AT creatinine ratio also provided good diagnostic performance (AUC 0.809, p = 0.001, sensitivity 81.8%, specificity 76.5%, accuracy 80%). Further development of non-invasive point-of-care tests using these biomarkers could be a fruitful future endeavor.
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spelling pubmed-90251252022-04-23 Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis Chen, Wei-Chun Cheng, Chao-Min Liao, Wan-Ting Chang, Ting-Chang Biomedicines Article Endometriosis or adenomyosis can be clinically diagnosed by ultrasound, symptoms, physical examination, and serum CA125. The urinary markers need to be investigated. The aim of our study was to investigate the urinary markers of clinical endometriosis/adenomyosis, and the correlation of serum CA125 was also studied. From the literature, alpha-1 antitrypsin (A1AT), enolase-1, vitamin D binding protein (VDBP), and CA125 in urine and serum were used in our study and measured by enzyme-linked immunosorbent assays (ELISA). Further clinical correlation and detection performance were evaluated. We enrolled 19 normal controls and 33 patients clinically diagnosed with endometriosis/adenomyosis. There were significant differences between studied patients and normal controls, as follows: serum CA125 (130.91 vs. 19.75 U/mL, p = 0.004); urinary CA125-creatinine ratio (5.591 vs. 0.254 ng/mg, p = 0.028); and urinary VDBP-creatinine ratio (28.028 vs. 7.301 ng/mg, p = 0.018). For diagnostic performances, serum CA125 provided the best results, with an area under curve (AUC) of 0.888 (p = 0.001) and accuracy of 86.5%. Other excellent results were also found using urinary VDBP (AUC 0.841, p = 0.001) and A1AT (AUC 0.722, p = 0.011) creatinine ratio. Using three combined biomarkers, serum CA125, urinary VDBP, and A1AT creatinine ratio, provided good detection power (AUC 0.913, p = 0.001, sensitivity 90.9%, specificity 76.5%). Double urine markers used in combination with VDBP and A1AT creatinine ratio also provided good diagnostic performance (AUC 0.809, p = 0.001, sensitivity 81.8%, specificity 76.5%, accuracy 80%). Further development of non-invasive point-of-care tests using these biomarkers could be a fruitful future endeavor. MDPI 2022-04-01 /pmc/articles/PMC9025125/ /pubmed/35453583 http://dx.doi.org/10.3390/biomedicines10040833 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Wei-Chun
Cheng, Chao-Min
Liao, Wan-Ting
Chang, Ting-Chang
Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis
title Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis
title_full Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis
title_fullStr Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis
title_full_unstemmed Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis
title_short Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis
title_sort urinary biomarkers for detection of clinical endometriosis or adenomyosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025125/
https://www.ncbi.nlm.nih.gov/pubmed/35453583
http://dx.doi.org/10.3390/biomedicines10040833
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