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The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis
Background: Fibrosis in pulmonary Langerhans cell histiocytosis (PLCH) histologically comprises a central scar with septal strands and associated airspace enlargement that produce an octopus-like appearance. The purpose of this study was to identify the octopus sign on high-resolution computed tomog...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025181/ https://www.ncbi.nlm.nih.gov/pubmed/35453983 http://dx.doi.org/10.3390/diagnostics12040937 |
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author | Poellinger, Alexander Berezowska, Sabina Myers, Jeffrey Leon Huber, Adrian Funke-Chambour, Manuela Guler, Sabina Geiser, Thomas Harari, Sergio Caminati, Antonella Zompatori, Maurizio Sverzellati, Nicola |
author_facet | Poellinger, Alexander Berezowska, Sabina Myers, Jeffrey Leon Huber, Adrian Funke-Chambour, Manuela Guler, Sabina Geiser, Thomas Harari, Sergio Caminati, Antonella Zompatori, Maurizio Sverzellati, Nicola |
author_sort | Poellinger, Alexander |
collection | PubMed |
description | Background: Fibrosis in pulmonary Langerhans cell histiocytosis (PLCH) histologically comprises a central scar with septal strands and associated airspace enlargement that produce an octopus-like appearance. The purpose of this study was to identify the octopus sign on high-resolution computed tomography (HRCT) images to determine its frequency and distribution across stages of the disease. Methods: Fifty-seven patients with confirmed PLCH were included. Two experienced chest radiologists assessed disease stages as early, intermediate, or late, as well as the lung parenchyma for nodular, cystic, or fibrotic changes and for the presence of the octopus sign. Statistical analysis included Cohen’s kappa for interrater agreement and Fisher’s exact test for the frequency of the octopus sign. Results: Interobserver agreement was substantial for the octopus sign (kappa = 0.747). Significant differences in distribution of the octopus sign between stages 2 and 3 were found with more frequent octopus signs in stage 2 and fewer in stage 3. In addition, we only found the octopus sign in cases of nodular und cystic lung disease. Conclusions: The octopus sign in PLCH can be identified not only on histological images, but also on HRCT images. Its radiological presence seems to depend on the stage of PLCH. |
format | Online Article Text |
id | pubmed-9025181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90251812022-04-23 The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis Poellinger, Alexander Berezowska, Sabina Myers, Jeffrey Leon Huber, Adrian Funke-Chambour, Manuela Guler, Sabina Geiser, Thomas Harari, Sergio Caminati, Antonella Zompatori, Maurizio Sverzellati, Nicola Diagnostics (Basel) Article Background: Fibrosis in pulmonary Langerhans cell histiocytosis (PLCH) histologically comprises a central scar with septal strands and associated airspace enlargement that produce an octopus-like appearance. The purpose of this study was to identify the octopus sign on high-resolution computed tomography (HRCT) images to determine its frequency and distribution across stages of the disease. Methods: Fifty-seven patients with confirmed PLCH were included. Two experienced chest radiologists assessed disease stages as early, intermediate, or late, as well as the lung parenchyma for nodular, cystic, or fibrotic changes and for the presence of the octopus sign. Statistical analysis included Cohen’s kappa for interrater agreement and Fisher’s exact test for the frequency of the octopus sign. Results: Interobserver agreement was substantial for the octopus sign (kappa = 0.747). Significant differences in distribution of the octopus sign between stages 2 and 3 were found with more frequent octopus signs in stage 2 and fewer in stage 3. In addition, we only found the octopus sign in cases of nodular und cystic lung disease. Conclusions: The octopus sign in PLCH can be identified not only on histological images, but also on HRCT images. Its radiological presence seems to depend on the stage of PLCH. MDPI 2022-04-08 /pmc/articles/PMC9025181/ /pubmed/35453983 http://dx.doi.org/10.3390/diagnostics12040937 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Poellinger, Alexander Berezowska, Sabina Myers, Jeffrey Leon Huber, Adrian Funke-Chambour, Manuela Guler, Sabina Geiser, Thomas Harari, Sergio Caminati, Antonella Zompatori, Maurizio Sverzellati, Nicola The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis |
title | The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis |
title_full | The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis |
title_fullStr | The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis |
title_full_unstemmed | The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis |
title_short | The Octopus Sign—A New HRCT Sign in Pulmonary Langerhans Cell Histiocytosis |
title_sort | octopus sign—a new hrct sign in pulmonary langerhans cell histiocytosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025181/ https://www.ncbi.nlm.nih.gov/pubmed/35453983 http://dx.doi.org/10.3390/diagnostics12040937 |
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