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Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution

Efficient separation of enantiomers is critical in the chemical, pharmaceutical, and food industries. However, conventional separation methods, such as chromatography, crystallization, and enzymatic kinetic resolution, require high energy costs and specific reaction conditions for the efficient puri...

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Detalles Bibliográficos
Autores principales: Choi, Hwa-Jin, Koh, Dong-Yeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025217/
https://www.ncbi.nlm.nih.gov/pubmed/35448327
http://dx.doi.org/10.3390/membranes12040357
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author Choi, Hwa-Jin
Koh, Dong-Yeun
author_facet Choi, Hwa-Jin
Koh, Dong-Yeun
author_sort Choi, Hwa-Jin
collection PubMed
description Efficient separation of enantiomers is critical in the chemical, pharmaceutical, and food industries. However, conventional separation methods, such as chromatography, crystallization, and enzymatic kinetic resolution, require high energy costs and specific reaction conditions for the efficient purification of one enantiomer. In contrast, membrane-based processes are continuous processes performed with less energy than conventional separation processes. Enantioselective polymer membranes have been developed for the chiral resolution of pharmaceuticals; however, it is difficult to generate sufficient enantiomeric excess (ee) with polymer membranes. In this work, a homochiral filler of L-His-ZIF-8 was synthesized by the ligand substitution method and mixed with polyamide(imide) (i.e., Torlon(®)) to fabricate an enantioselective mixed-matrix membrane (MMM). The enantio-selective separation of R-1-phenylethanol over S-1-phenylethanol was demonstrated with a 25 wt% loaded L-His-ZIF-8/Torlon(®) MMM in an organic solvent nanofiltration (OSN) mode.
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spelling pubmed-90252172022-04-23 Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution Choi, Hwa-Jin Koh, Dong-Yeun Membranes (Basel) Article Efficient separation of enantiomers is critical in the chemical, pharmaceutical, and food industries. However, conventional separation methods, such as chromatography, crystallization, and enzymatic kinetic resolution, require high energy costs and specific reaction conditions for the efficient purification of one enantiomer. In contrast, membrane-based processes are continuous processes performed with less energy than conventional separation processes. Enantioselective polymer membranes have been developed for the chiral resolution of pharmaceuticals; however, it is difficult to generate sufficient enantiomeric excess (ee) with polymer membranes. In this work, a homochiral filler of L-His-ZIF-8 was synthesized by the ligand substitution method and mixed with polyamide(imide) (i.e., Torlon(®)) to fabricate an enantioselective mixed-matrix membrane (MMM). The enantio-selective separation of R-1-phenylethanol over S-1-phenylethanol was demonstrated with a 25 wt% loaded L-His-ZIF-8/Torlon(®) MMM in an organic solvent nanofiltration (OSN) mode. MDPI 2022-03-24 /pmc/articles/PMC9025217/ /pubmed/35448327 http://dx.doi.org/10.3390/membranes12040357 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Hwa-Jin
Koh, Dong-Yeun
Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
title Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
title_full Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
title_fullStr Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
title_full_unstemmed Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
title_short Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
title_sort homochiral metal-organic framework based mixed matrix membrane for chiral resolution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025217/
https://www.ncbi.nlm.nih.gov/pubmed/35448327
http://dx.doi.org/10.3390/membranes12040357
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