Cargando…

Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America

Numerous antimicrobial resistance (AMR) surveillance studies have been conducted in North American feedlot cattle to investigate the major bacterial pathogens of the bovine respiratory disease (BRD) complex, specifically: Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplas...

Descripción completa

Detalles Bibliográficos
Autores principales: Andrés-Lasheras, Sara, Jelinski, Murray, Zaheer, Rahat, McAllister, Tim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025279/
https://www.ncbi.nlm.nih.gov/pubmed/35453238
http://dx.doi.org/10.3390/antibiotics11040487
_version_ 1784690830313783296
author Andrés-Lasheras, Sara
Jelinski, Murray
Zaheer, Rahat
McAllister, Tim A.
author_facet Andrés-Lasheras, Sara
Jelinski, Murray
Zaheer, Rahat
McAllister, Tim A.
author_sort Andrés-Lasheras, Sara
collection PubMed
description Numerous antimicrobial resistance (AMR) surveillance studies have been conducted in North American feedlot cattle to investigate the major bacterial pathogens of the bovine respiratory disease (BRD) complex, specifically: Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. While most bacterial isolates recovered from healthy cattle are susceptible to a repertoire of antimicrobials, multidrug resistance is common in isolates recovered from cattle suffering from BRD. Integrative and conjugative elements (ICE) have gained increasing notoriety in BRD-Pasteurellaceae as they appear to play a key role in the concentration and dissemination of antimicrobial resistant genes. Likewise, low macrolide susceptibility has been described in feedlot isolates of M. bovis. Horizontal gene transfer has also been implicated in the spread of AMR within mycoplasmas, and in-vitro experiments have shown that exposure to antimicrobials can generate high levels of resistance in mycoplasmas via a single conjugative event. Consequently, antimicrobial use (AMU) could be accelerating AMR horizontal transfer within all members of the bacterial BRD complex. While metagenomics has been applied to the study of AMR in the microbiota of the respiratory tract, the potential role of the respiratory tract microbiome as an AMR reservoir remains uncertain. Current and prospective molecular tools to survey and characterize AMR need to be adapted as point-of-care technologies to enhance prudent AMU in the beef industry.
format Online
Article
Text
id pubmed-9025279
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90252792022-04-23 Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America Andrés-Lasheras, Sara Jelinski, Murray Zaheer, Rahat McAllister, Tim A. Antibiotics (Basel) Review Numerous antimicrobial resistance (AMR) surveillance studies have been conducted in North American feedlot cattle to investigate the major bacterial pathogens of the bovine respiratory disease (BRD) complex, specifically: Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. While most bacterial isolates recovered from healthy cattle are susceptible to a repertoire of antimicrobials, multidrug resistance is common in isolates recovered from cattle suffering from BRD. Integrative and conjugative elements (ICE) have gained increasing notoriety in BRD-Pasteurellaceae as they appear to play a key role in the concentration and dissemination of antimicrobial resistant genes. Likewise, low macrolide susceptibility has been described in feedlot isolates of M. bovis. Horizontal gene transfer has also been implicated in the spread of AMR within mycoplasmas, and in-vitro experiments have shown that exposure to antimicrobials can generate high levels of resistance in mycoplasmas via a single conjugative event. Consequently, antimicrobial use (AMU) could be accelerating AMR horizontal transfer within all members of the bacterial BRD complex. While metagenomics has been applied to the study of AMR in the microbiota of the respiratory tract, the potential role of the respiratory tract microbiome as an AMR reservoir remains uncertain. Current and prospective molecular tools to survey and characterize AMR need to be adapted as point-of-care technologies to enhance prudent AMU in the beef industry. MDPI 2022-04-05 /pmc/articles/PMC9025279/ /pubmed/35453238 http://dx.doi.org/10.3390/antibiotics11040487 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Andrés-Lasheras, Sara
Jelinski, Murray
Zaheer, Rahat
McAllister, Tim A.
Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
title Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
title_full Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
title_fullStr Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
title_full_unstemmed Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
title_short Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
title_sort bovine respiratory disease: conventional to culture-independent approaches to studying antimicrobial resistance in north america
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025279/
https://www.ncbi.nlm.nih.gov/pubmed/35453238
http://dx.doi.org/10.3390/antibiotics11040487
work_keys_str_mv AT andreslasherassara bovinerespiratorydiseaseconventionaltocultureindependentapproachestostudyingantimicrobialresistanceinnorthamerica
AT jelinskimurray bovinerespiratorydiseaseconventionaltocultureindependentapproachestostudyingantimicrobialresistanceinnorthamerica
AT zaheerrahat bovinerespiratorydiseaseconventionaltocultureindependentapproachestostudyingantimicrobialresistanceinnorthamerica
AT mcallistertima bovinerespiratorydiseaseconventionaltocultureindependentapproachestostudyingantimicrobialresistanceinnorthamerica