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Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases

A unique case of multiple metastatic melanoma skin nodules regression in a heavily pretreated, 72-year-old Caucasian female, after administering the second dose of the SARS-CoV-2 mRNA Pfizer-BioNTech vaccine, is presented. Two days after vaccination, all her melanoma skin nodules became painful and...

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Autores principales: Bafaloukos, Dimitrios, Petraki, Kalliopi, Bousmpoukea, Aikaterini, Chatzichristou, Eleni, Pieris, Ioannis, Koutserimpas, Christos, Samonis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025412/
https://www.ncbi.nlm.nih.gov/pubmed/35455274
http://dx.doi.org/10.3390/vaccines10040525
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author Bafaloukos, Dimitrios
Petraki, Kalliopi
Bousmpoukea, Aikaterini
Chatzichristou, Eleni
Pieris, Ioannis
Koutserimpas, Christos
Samonis, George
author_facet Bafaloukos, Dimitrios
Petraki, Kalliopi
Bousmpoukea, Aikaterini
Chatzichristou, Eleni
Pieris, Ioannis
Koutserimpas, Christos
Samonis, George
author_sort Bafaloukos, Dimitrios
collection PubMed
description A unique case of multiple metastatic melanoma skin nodules regression in a heavily pretreated, 72-year-old Caucasian female, after administering the second dose of the SARS-CoV-2 mRNA Pfizer-BioNTech vaccine, is presented. Two days after vaccination, all her melanoma skin nodules became painful and were significantly reduced in size. Physical examination and ultrasound imaging confirmed the patient’s observation. The effect was sustained, and further reduction of the nodules occurred after the third vaccine dose. One of the reduced nodules was removed, histologically examined, and its histopathology was compared to that of another such nodule removed and examined earlier. Distinct differences were observed between the two histopathologies, with the most notable the unexpected finding of the absence of infiltrating lymphocytes in the reducer nodule’s melanoma tissue. Based on this observation, the possible immunological mechanism(s) leading to the vaccine’s effect are speculated. More possible is the vaccine’s antitumor and apoptotic activity via stimulation of the Tol Like Receptors 3, 7, and 8, and (downstream) the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway of the non-lymphocytic immune effector cells.
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spelling pubmed-90254122022-04-23 Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases Bafaloukos, Dimitrios Petraki, Kalliopi Bousmpoukea, Aikaterini Chatzichristou, Eleni Pieris, Ioannis Koutserimpas, Christos Samonis, George Vaccines (Basel) Case Report A unique case of multiple metastatic melanoma skin nodules regression in a heavily pretreated, 72-year-old Caucasian female, after administering the second dose of the SARS-CoV-2 mRNA Pfizer-BioNTech vaccine, is presented. Two days after vaccination, all her melanoma skin nodules became painful and were significantly reduced in size. Physical examination and ultrasound imaging confirmed the patient’s observation. The effect was sustained, and further reduction of the nodules occurred after the third vaccine dose. One of the reduced nodules was removed, histologically examined, and its histopathology was compared to that of another such nodule removed and examined earlier. Distinct differences were observed between the two histopathologies, with the most notable the unexpected finding of the absence of infiltrating lymphocytes in the reducer nodule’s melanoma tissue. Based on this observation, the possible immunological mechanism(s) leading to the vaccine’s effect are speculated. More possible is the vaccine’s antitumor and apoptotic activity via stimulation of the Tol Like Receptors 3, 7, and 8, and (downstream) the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway of the non-lymphocytic immune effector cells. MDPI 2022-03-28 /pmc/articles/PMC9025412/ /pubmed/35455274 http://dx.doi.org/10.3390/vaccines10040525 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bafaloukos, Dimitrios
Petraki, Kalliopi
Bousmpoukea, Aikaterini
Chatzichristou, Eleni
Pieris, Ioannis
Koutserimpas, Christos
Samonis, George
Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases
title Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases
title_full Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases
title_fullStr Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases
title_full_unstemmed Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases
title_short Therapeutic Effect of mRNA SARS-CoV-2 Vaccine on Melanoma Skin Metastases
title_sort therapeutic effect of mrna sars-cov-2 vaccine on melanoma skin metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025412/
https://www.ncbi.nlm.nih.gov/pubmed/35455274
http://dx.doi.org/10.3390/vaccines10040525
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