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COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond

SIMPLE SUMMARY: Coronavirus disease-2019 (COVID-19) affects many organs in the body, including the heart. One complication of particular concern is inflammation of the heart muscle, called myocarditis. This paper presents updated research data on COVID-19-associated myocarditis. Specifically, we rev...

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Autores principales: Fraser, Meg, Agdamag, Arianne Clare C., Maharaj, Valmiki R., Mutschler, Melinda, Charpentier, Victoria, Chowdhury, Mohammed, Alexy, Tamas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025425/
https://www.ncbi.nlm.nih.gov/pubmed/35453718
http://dx.doi.org/10.3390/biology11040520
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author Fraser, Meg
Agdamag, Arianne Clare C.
Maharaj, Valmiki R.
Mutschler, Melinda
Charpentier, Victoria
Chowdhury, Mohammed
Alexy, Tamas
author_facet Fraser, Meg
Agdamag, Arianne Clare C.
Maharaj, Valmiki R.
Mutschler, Melinda
Charpentier, Victoria
Chowdhury, Mohammed
Alexy, Tamas
author_sort Fraser, Meg
collection PubMed
description SIMPLE SUMMARY: Coronavirus disease-2019 (COVID-19) affects many organs in the body, including the heart. One complication of particular concern is inflammation of the heart muscle, called myocarditis. This paper presents updated research data on COVID-19-associated myocarditis. Specifically, we review the incidence, potential mechanisms, blood and imaging tests that can be used to detect the disease. We emphasize that, in contrast with early reports, recent data suggest that myocarditis in the setting of COVID-19 is relatively uncommon, yet infected individuals are at a substantially increased risk for poor outcomes. It is important to continue research in this area. ABSTRACT: The direct and indirect adverse effects of SARS-CoV-2 infection on the cardiovascular system, including myocarditis, are of paramount importance. These not only affect the disease course but also determine clinical outcomes and recovery. In this review, the authors aimed at providing an update on the incidence of Coronavirus disease-2019 (COVID-19)-associated myocarditis. Our knowledge and experience relevant to this area continues to evolve rapidly since the beginning of the pandemic. It is crucial for the scientific and medical community to stay abreast of current information. Contrasting early reports, recent data suggest that the overall incidence of SARS-CoV-2-associated myocarditis is relatively low, yet infected individuals are at a substantially increased risk. Therefore, understanding the pathophysiology and diagnostic evaluation, including the use of serum biomarkers and imaging modalities, remain important. This review aims to summarize the most recent data in these areas as they relate to COVID-19-associated myocarditis. Given its increasing relevance, a brief update is included on the proposed mechanisms of myocarditis in COVID-19 vaccine recipients.
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spelling pubmed-90254252022-04-23 COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond Fraser, Meg Agdamag, Arianne Clare C. Maharaj, Valmiki R. Mutschler, Melinda Charpentier, Victoria Chowdhury, Mohammed Alexy, Tamas Biology (Basel) Review SIMPLE SUMMARY: Coronavirus disease-2019 (COVID-19) affects many organs in the body, including the heart. One complication of particular concern is inflammation of the heart muscle, called myocarditis. This paper presents updated research data on COVID-19-associated myocarditis. Specifically, we review the incidence, potential mechanisms, blood and imaging tests that can be used to detect the disease. We emphasize that, in contrast with early reports, recent data suggest that myocarditis in the setting of COVID-19 is relatively uncommon, yet infected individuals are at a substantially increased risk for poor outcomes. It is important to continue research in this area. ABSTRACT: The direct and indirect adverse effects of SARS-CoV-2 infection on the cardiovascular system, including myocarditis, are of paramount importance. These not only affect the disease course but also determine clinical outcomes and recovery. In this review, the authors aimed at providing an update on the incidence of Coronavirus disease-2019 (COVID-19)-associated myocarditis. Our knowledge and experience relevant to this area continues to evolve rapidly since the beginning of the pandemic. It is crucial for the scientific and medical community to stay abreast of current information. Contrasting early reports, recent data suggest that the overall incidence of SARS-CoV-2-associated myocarditis is relatively low, yet infected individuals are at a substantially increased risk. Therefore, understanding the pathophysiology and diagnostic evaluation, including the use of serum biomarkers and imaging modalities, remain important. This review aims to summarize the most recent data in these areas as they relate to COVID-19-associated myocarditis. Given its increasing relevance, a brief update is included on the proposed mechanisms of myocarditis in COVID-19 vaccine recipients. MDPI 2022-03-28 /pmc/articles/PMC9025425/ /pubmed/35453718 http://dx.doi.org/10.3390/biology11040520 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fraser, Meg
Agdamag, Arianne Clare C.
Maharaj, Valmiki R.
Mutschler, Melinda
Charpentier, Victoria
Chowdhury, Mohammed
Alexy, Tamas
COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond
title COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond
title_full COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond
title_fullStr COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond
title_full_unstemmed COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond
title_short COVID-19-Associated Myocarditis: An Evolving Concern in Cardiology and Beyond
title_sort covid-19-associated myocarditis: an evolving concern in cardiology and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025425/
https://www.ncbi.nlm.nih.gov/pubmed/35453718
http://dx.doi.org/10.3390/biology11040520
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